Regenerative nodule mimicking hepatocellular carcinoma in a cirrhotic child due to hepatitis B: An imaging dilemma

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dc.contributor.authorOzgenc, F
dc.contributor.authorAydogdu, S
dc.contributor.authorAksoylar, S
dc.contributor.authorElmas, N
dc.contributor.authorYuce, G
dc.contributor.authorYagci, RV
dc.contributor.authorTokat, Y
dc.date.accessioned2019-10-27T19:04:36Z
dc.date.available2019-10-27T19:04:36Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractViral hepatitis B, post-hepatitic cirrhosis and hepatocellular carcinoma (HCC) is the classical sequence of events in hepatitis B virus (HBV) infected children and serum Alpha-fetoprotein (AFP) and ultrasound (USG) screening is recommended during follow up. We present a 13-yr-old girl with cirrhosis related to chronic HBV infection with normal AFP level and a 4 cm mass appearance by USG. Contrast spiral evaluation computed tomography (CT) study demonstrated a single mass located at 8th segment of the liver. Pre-contrast CT and portal venous phase studies showed heterogeneous liver parenchyma without mass appearance. HCC was suspected based on strong arterial enhancement. Two mediastinal lymphadenopathies, 1 cm under the xyphoid and 2 cm above the pericardium, were detected by thorax CT. Mediastinal exploration was undertaken with living related liver transplant donor in a second operating room. She was transplanted with the right lobe of her ABO compatible mother after evaluation of the lymph nodes revealed reactive histology by frozen section. Histologic evaluation of the explant liver documented cirrhosis with a cirrhotic nodule without histologic malignant evidence. False negative results from screening methods are familiar in the literature; however false positivity of a contrast CT study is rare. The significance of screening methods is discussed.en_US
dc.identifier.doi10.1046/j.1399-3046.2003.00019.xen_US
dc.identifier.endpage200en_US
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue2en_US
dc.identifier.pmid15049804en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.1046/j.1399-3046.2003.00019.x
dc.identifier.urihttps://hdl.handle.net/11454/38221
dc.identifier.volume8en_US
dc.identifier.wosWOS:000220486000019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthepatocellular carcinomaen_US
dc.subjecthepatitis B virusen_US
dc.subjectimaging studyen_US
dc.titleRegenerative nodule mimicking hepatocellular carcinoma in a cirrhotic child due to hepatitis B: An imaging dilemmaen_US
dc.typeArticleen_US

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