Factors affecting TST level in patients undergoing dialysis: a multicenter study

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dc.contributor.authorDeniz, Sami
dc.contributor.authorAydemir, Yusuf
dc.contributor.authorSengul, Aysun
dc.contributor.authorEmre, Julide Celdir
dc.contributor.authorTanrisev, Mehmet
dc.contributor.authorOzhan, Mustafa Hikmet
dc.contributor.authorGuney, Ibrahim
dc.date.accessioned2019-10-27T09:59:07Z
dc.date.available2019-10-27T09:59:07Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: The risk of TB is increased in patients with chronic kidney disease (CKD) when compared with individuals with normal renal function. We aimed to determine tuberculin skin test (TST) response and the factors which might affect the response in patients with CKD undergoing dialysis in this study. Methods: The purified protein derivative solution was administered to the patients and the diameter of induration was measured. Additionally, the age, gender and smoking status of the patients were interrogated. Comorbidities were recorded both by patients' self-reports and data from the hospital files. The number of Bacille Calmette-Guerin (BCG) scars was recorded by checking both shoulders. Findings: The study was conducted with a total of 371 patients (194 men and 177 women). The mean age was 60.09 +/- 15.88, TST was 6.99 +/- 6.9, duration of dialysis was 4.44 +/- 4.5 (3.8-0.1,24). A total of 229 patients have comorbodities (61.7%, the most frequent was hypertension). Logistic regression model was performed. Gender, vitamin D treatment and high parathormone (PTH) levels remained in the final stage of the analysis and vitamin D intake and PTH levels were detected to be statistically significant (P = 0.002, 0.007, respectively). Discussion: This study is the first study which showed a correlation between TST negativity and increased PTH levels and receiving vitamin D treatment. Starting from this point, it was concluded that PTH may suppress the immune system and especially cellular immunity.en_US
dc.identifier.doi10.1111/hdi.12676en_US
dc.identifier.endpage87en_US
dc.identifier.issn1492-7535
dc.identifier.issn1542-4758
dc.identifier.issue1en_US
dc.identifier.pmid30289192en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1111/hdi.12676
dc.identifier.urihttps://hdl.handle.net/11454/29568
dc.identifier.volume23en_US
dc.identifier.wosWOS:000459488600011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHemodialysis Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemodialysisen_US
dc.subjecttuberculin skin testen_US
dc.subjectparathormoneen_US
dc.subjectvitamin Den_US
dc.titleFactors affecting TST level in patients undergoing dialysis: a multicenter studyen_US
dc.typeArticleen_US

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