Antimicrobial and cytotoxic studies of new 2-substitue-1H-benzimidazole derivatives [Yeni 2-sübstitüe-1H-benzimidazol türevi bileşikler üzerinde antimikrobiyal ve sitotoksik çali{dotless}şmalar]

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dc.contributor.authorSarikaya G.
dc.contributor.authorAlpan A.S.
dc.contributor.authorTaşli H.
dc.contributor.authorSevin G.
dc.contributor.authorKorkmaz C.G.
dc.contributor.authorGüneş H.S.
dc.date.accessioned2019-10-26T22:15:46Z
dc.date.available2019-10-26T22:15:46Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractWe synthesized a series of 2-substituted-1H-benzimidazole derivatives (1-9) of which six of them were original and elucidated their structures by spectral analyses. We also evaluated the in-vitro antimicrobial activities of the synthesized compounds and detected potent inhibitory action in some of the compounds. Moreover, 2-(1H-benzimidazole-2-yl)phenol intermediates, bearing o-hydroxyphenyl substituent on 1H-benzimidazole ring possess equal or similar results compared to the standard compound, Ceftazidime. The synthesized compounds didn't show any significant antifungal activity on Candida albicans. All nine 1H-benzimidazole derivatives were tested for their cytotoxicity through WST-1 colorimetric assay-based in vitro tests on the mammalian LNCaP cell line. Compounds 7 and 8 were found to have IC50 values of 0,09 ± 0,01 µM and 0,03 ± 0,02 µM, respectively. It is noteworthy that the values obtained with these two compounds were highly comparable to that of Doxorubicine 0,053 ± 0,003 µM, the reference drug used in our study.en_US
dc.identifier.endpage392en_US
dc.identifier.issn1307-2080
dc.identifier.issn1307-2080en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://hdl.handle.net/11454/19410
dc.identifier.volume53en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversity of Istanbulen_US
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAntifungalen_US
dc.subjectBenzimidazolesen_US
dc.subjectCytotoxicityen_US
dc.subjectSynthesisen_US
dc.titleAntimicrobial and cytotoxic studies of new 2-substitue-1H-benzimidazole derivatives [Yeni 2-sübstitüe-1H-benzimidazol türevi bileşikler üzerinde antimikrobiyal ve sitotoksik çali{dotless}şmalar]en_US
dc.typeArticleen_US

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