Antimicrobial and cytotoxic studies of new 2-substitue-1H-benzimidazole derivatives [Yeni 2-sübstitüe-1H-benzimidazol türevi bileşikler üzerinde antimikrobiyal ve sitotoksik çali{dotless}şmalar]
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Istanbul
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We synthesized a series of 2-substituted-1H-benzimidazole derivatives (1-9) of which six of them were original and elucidated their structures by spectral analyses. We also evaluated the in-vitro antimicrobial activities of the synthesized compounds and detected potent inhibitory action in some of the compounds. Moreover, 2-(1H-benzimidazole-2-yl)phenol intermediates, bearing o-hydroxyphenyl substituent on 1H-benzimidazole ring possess equal or similar results compared to the standard compound, Ceftazidime. The synthesized compounds didn't show any significant antifungal activity on Candida albicans. All nine 1H-benzimidazole derivatives were tested for their cytotoxicity through WST-1 colorimetric assay-based in vitro tests on the mammalian LNCaP cell line. Compounds 7 and 8 were found to have IC50 values of 0,09 ± 0,01 µM and 0,03 ± 0,02 µM, respectively. It is noteworthy that the values obtained with these two compounds were highly comparable to that of Doxorubicine 0,053 ± 0,003 µM, the reference drug used in our study.
Açıklama
Anahtar Kelimeler
Antibacterial, Antifungal, Benzimidazoles, Cytotoxicity, Synthesis
Kaynak
Acta Pharmaceutica Sciencia
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
53
Sayı
3
