THE EFFECTS OF THIAZIDE AND THIAZIDE-LIKE DIURETICS ON THE RELATIONSHIP BETWEEN NORMAL SERUM URIC ACID LEVELS AND COGNITIVE FUNCTION

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dc.authoridkayhan kocak, fatma ozge/0000-0002-6447-2352
dc.authoridErtuna, Elif/0000-0001-9061-146X
dc.authoridSarac, Zeliha Fulden/0000-0001-9281-2492
dc.authorscopusid57220026360
dc.authorscopusid57208340037
dc.authorscopusid15080556500
dc.authorscopusid56332865400
dc.authorscopusid36572380900
dc.authorscopusid16175846400
dc.authorscopusid56042161900
dc.authorwosidkayhan kocak, fatma ozge/GPX-2006-2022
dc.authorwosidErtuna, Elif/FCA-0794-2022
dc.contributor.authorKayhan Kocak, Fatma Ozge
dc.contributor.authorAy, Seval
dc.contributor.authorErtuna, Elif
dc.contributor.authorArun, Mehmet Zuhuri
dc.contributor.authorSahin, Sevnaz
dc.contributor.authorSarac, Zeliha Fulden
dc.contributor.authorAkcicek, Selahattin Fehmi
dc.date.accessioned2023-01-12T20:15:16Z
dc.date.available2023-01-12T20:15:16Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractIntroduction: The objective of this study was to identify the possible effect of thiazide and thiazide-like diuretic use on the relationship between uric acid and cognitive function in geriatric patients with normal renal function. Method: Serum uric acid levels and Mini-Mental State Examination scores of 238 patients (age >= 65 years) treated in an outpatient geriatric clinic were evaluated in this observational, cross-sectional, retrospective study. The effect of thiazide diuretic use on Mini-Mental State Examination score was also assessed. Results: Compared to patients that are not currently taking thiazide diuretics (non-thiazide group) serum uric acid was significantly higher in patients using thiazide and thiazide-like diuretics (thiazide group) (5.27 +/- 0.12 vs 6.09 +/- 0.20; P< 0.001). Although the serum uric acid levels were higher in the thiazide group the Mini-Mental State Examination scores were similar to the non-thiazide group. There was a strong positive correlation between serum uric acid levels and Mini-Mental State Examination score in both groups (P< 0.001). The Mini-Mental State Examination score was significantly lower in the lowest serum uric acid quartile in both groups (P< 0.001). Conclusions: Low serum uric acid levels are associated with cognitive impairment; a slight but significant increase of serum uric acid due to thiazide diuretic use does not seem to enhance cognitive function in geriatric patients.en_US
dc.identifier.doi10.31086/tjgeri.2021.250
dc.identifier.endpage533en_US
dc.identifier.issn1304-2947
dc.identifier.issn1307-9948
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85121850043en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage526en_US
dc.identifier.trdizinid505435en_US
dc.identifier.urihttps://doi.org/10.31086/tjgeri.2021.250
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/505435
dc.identifier.urihttps://hdl.handle.net/11454/78402
dc.identifier.volume24en_US
dc.identifier.wosWOS:000737328600010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGunes Kitabevi Ltd Stien_US
dc.relation.ispartofTurkish Journal Of Geriatrics-Turk Geriatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDementiaen_US
dc.subjectCognitive Dysfunctionen_US
dc.subjectGeriatric Assessmenten_US
dc.subjectUric Aciden_US
dc.subjectSodium Chloride Symporter Inhibitorsen_US
dc.subjectAgeden_US
dc.subjectAssociationen_US
dc.subjectDiseaseen_US
dc.subjectDementiaen_US
dc.titleTHE EFFECTS OF THIAZIDE AND THIAZIDE-LIKE DIURETICS ON THE RELATIONSHIP BETWEEN NORMAL SERUM URIC ACID LEVELS AND COGNITIVE FUNCTIONen_US
dc.typeArticleen_US

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