Cycloartane-type sapogenol derivatives inhibit NF kappa B activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis

Basit Öğe Kaydı
dc.contributor.authorDebelec-Butuner, Bilge
dc.contributor.authorOzturk, Mert Burak
dc.contributor.authorTag, Ozgur
dc.contributor.authorAkgun, Ismail Hakki
dc.contributor.authorYetik-Anacak, Gunay
dc.contributor.authorBedir, Erdal
dc.contributor.authorKorkmaz, Kemal Sami
dc.date.accessioned2019-10-27T10:04:17Z
dc.date.available2019-10-27T10:04:17Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractChronic inflammation is associated to 25% of cancer cases according to epidemiological data. Therefore, inhibition of inflammation-induced carcinogenesis can be an efficient therapeutic approach for cancer chemoprevention in drug development studies. It is also determined that anti-inflammatory drugs reduce cancer incidence. Cell culture-based in vitro screening methods are used as a fast and efficient method to investigate the biological activities of the biomolecules. In addition, saponins are molecules that are isolated from natural sources and are known to have potential for tumor inhibition. Studies on the preparation of analogues of cycloartane-type sapogenols (9,19-cyclolanostanes) have so far been limited. Therefore we have decided to direct our efforts toward the exploration of new anti-tumor agents prepared from cycloastragenol and its production artifact astragenol. The semi-synthetic derivatives were prepared mainly by oxidation, condensation, alkylation, acylation, and elimination reactions. After preliminary studies, five sapogenol analogues, two of which were new compounds (2 and 3), were selected and screened for their inhibitory activity on cell viability and NF kappa B signaling pathway activity in LNCaP prostate cancer cells. We found that the astragenol derivatives 1 and 2 as well as cycloastragenol derivatives 3, 4, and 5 exhibited strong inhibitory activity on NF kappa B signaling leading the repression of NF kappa B transcriptional activation and suppressed cell proliferation. The results suggested that these molecules might have significant potential for chemoprevention of prostate carcinogenesis induced by inflammatory NF kappa B signaling pathway.en_US
dc.description.sponsorshipTurkish Scientific and Technological Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z078]en_US
dc.description.sponsorshipThis work was supported by Turkish Scientific and Technological Research Council (TUBITAK) with the project number 113Z078 to BDB.en_US
dc.identifier.doi10.1016/j.steroids.2018.04.005en_US
dc.identifier.endpage20en_US
dc.identifier.issn0039-128X
dc.identifier.issn1878-5867
dc.identifier.pmid29678446en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.1016/j.steroids.2018.04.005
dc.identifier.urihttps://hdl.handle.net/11454/30219
dc.identifier.volume135en_US
dc.identifier.wosWOS:000434746900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofSteroidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstragenolen_US
dc.subjectCycloastragenolen_US
dc.subjectSemi-synthesisen_US
dc.subjectProstate cancer chemopreventionen_US
dc.subjectInflammation-induced carcinogenesisen_US
dc.subjectNF kappa Ben_US
dc.titleCycloartane-type sapogenol derivatives inhibit NF kappa B activation as chemopreventive strategy for inflammation-induced prostate carcinogenesisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu