Autoantibodies other than antineutrophil cytoplasmic antibodies are not positive in patients with psoriasis vulgaris

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dc.contributor.authorKutukculer N.
dc.contributor.authorYuksel S.E.
dc.contributor.authorAksu G.
dc.contributor.authorAlper S.
dc.date.accessioned2019-10-27T00:11:31Z
dc.date.available2019-10-27T00:11:31Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractThere is a great deal of evidences that a link may exist between psoriasis and autoimmunity. In this study, thirty-six patients with psoriasis vulgaris and twenty healthy controls were screened for antinuclear antibody (ANA), anti-ds-DNA antibodies, anti-SSA (anti-Ro), anti-SSB (anti-La), anti-Scl-70, anti-Jo-1, rheumatoid factor (RF), C3 and C4 levels, IgG and IgM anti-cardiolipin antibodies (aCL) and anti-neutrophil cytoplasmic antibodies (pANCA and cANCA) in order to determine the role of autoimmunity in the pathogenesis. In addition, the MPO-ANCA test was performed on pANCA-positive patients. In ANA screening, one patient showed 1/80 granular positivity. No positive results were obtained from either the study or control groups for anti-dsDNA, anti-SSA, anti-SSB, anti-Scl-70, or anti-Jo-1 determinations. For RF, 5.8% of the patients had positive values. Both C3 and C4 levels were found to be significantly elevated in psoriasis patients compared to healthy controls (p<0.001). IgG-aCL and IgM-aCL positivity was not significantly different between the two group. pANCA was positive in 33.3% of the patients and a significant difference was observed between study and control groups (p<0.05). MPO-ANCA was negative in all the pANCA-positive patiente. In conclusion, only serum C3 and C4 levels and pANCA determinations showed significant differences when compared to healthy controls. Our findings may be evidence of associations between autoimmunity and psoriasis vulgaris. However, more detailed studies in this field need to be done to determine the relationship between them.en_US
dc.identifier.doi10.1111/j.1346-8138.2005.tb00741.xen_US
dc.identifier.endpage185en_US
dc.identifier.issn0385-2407
dc.identifier.issue3en_US
dc.identifier.pmid15863863en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage179en_US
dc.identifier.urihttps://doi.org/10.1111/j.1346-8138.2005.tb00741.x
dc.identifier.urihttps://hdl.handle.net/11454/22189
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapanese Dermatological Associationen_US
dc.relation.ispartofJournal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectANCAen_US
dc.subjectAntinuclear antibodiesen_US
dc.subjectComplementen_US
dc.subjectPsoriasis vulgarisen_US
dc.titleAutoantibodies other than antineutrophil cytoplasmic antibodies are not positive in patients with psoriasis vulgarisen_US
dc.typeArticleen_US

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