Mechanisms of action of intravenous immunoglobulins [İntravenöz i·mmünglobulinlerin etki mekanizmalari]

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dc.contributor.authorGenel F.
dc.contributor.authorKütükçüler N.
dc.date.accessioned2019-10-27T00:23:58Z
dc.date.available2019-10-27T00:23:58Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractIntravenous immunoglobulin was originally developed for the treatment of primary immunodeficiencies and subsequently it has been used increasingly in the treatment of patients with autoimmune and inflammatory diseases with beneficial effects. The mode of action of intravenous immunoglobulin is probably multiple distinct mechanisms involving Fc receptor blockade, inhibition of complement binding, modulation of cytokine production, restoration of the idiotypic network and neutralization of pathogenic autoantibodies, modulation of T and B cell activation and differentiation. This article discusses the proposed mechanisms of action of intravenous immunoglobulin in various disorders.en_US
dc.identifier.endpage220en_US
dc.identifier.issn1301-8825
dc.identifier.issn1301-8825en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://hdl.handle.net/11454/22960
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTHOD - Turk Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmune diseasesen_US
dc.subjectInflammatory diseasesen_US
dc.subjectIntravenous immunoglobulinen_US
dc.subjectMechanisms of actionen_US
dc.titleMechanisms of action of intravenous immunoglobulins [İntravenöz i·mmünglobulinlerin etki mekanizmalari]en_US
dc.typeReview Articleen_US

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