Mechanisms of action of intravenous immunoglobulins [İntravenöz i·mmünglobulinlerin etki mekanizmalari]
Küçük Resim Yok
Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Intravenous immunoglobulin was originally developed for the treatment of primary immunodeficiencies and subsequently it has been used increasingly in the treatment of patients with autoimmune and inflammatory diseases with beneficial effects. The mode of action of intravenous immunoglobulin is probably multiple distinct mechanisms involving Fc receptor blockade, inhibition of complement binding, modulation of cytokine production, restoration of the idiotypic network and neutralization of pathogenic autoantibodies, modulation of T and B cell activation and differentiation. This article discusses the proposed mechanisms of action of intravenous immunoglobulin in various disorders.
Açıklama
Anahtar Kelimeler
Autoimmune diseases, Inflammatory diseases, Intravenous immunoglobulin, Mechanisms of action
Kaynak
THOD - Turk Hematoloji-Onkoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
12
Sayı
4
