4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

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dc.contributor.authorKaradeniz, Muammer
dc.contributor.authorErdogan, Mehmet
dc.contributor.authorBerdeli, Afig
dc.contributor.authorSaygili, Fusun
dc.contributor.authorYilmaz, Candeger
dc.date.accessioned2019-10-27T19:32:44Z
dc.date.available2019-10-27T19:32:44Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose Polycystic ovary syndrome (PCOS) is one of the most encountered endocrine malfunctions. PCOS patients have enhanced activation of the blood coagulation system. Methods Eighty-six young women with PCOS and 70 healthy control women were included in our study. PCOS patients and controls were matched for age, body mass index, and allele frequency. Genetic analysis of TPAI and PAI-1 were performed in all subjects. Results and conclusions No statistically significant differences have been detected about the ratios of genotypes resulting from PAI-1 promotor 4G/5G gene polymorphism. PAI-1 765 4G/5G gene polymorphism and TPA gene's Alu-repeat insertion/deletion (I/D) polymorphism ratios were not different from the controls. In this study it is shown by the analysis of TPA gene's Alu-repeat insertion/deletion (I/D) polymorphism the PCOS patients with genotype II had lowers total cholesterol and LDL-cholesterol levels.en_US
dc.identifier.doi10.1007/s10815-007-9160-7en_US
dc.identifier.endpage418en_US
dc.identifier.issn1058-0468
dc.identifier.issue9en_US
dc.identifier.pmid17661167en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage412en_US
dc.identifier.urihttps://doi.org/10.1007/s10815-007-9160-7
dc.identifier.urihttps://hdl.handle.net/11454/39345
dc.identifier.volume24en_US
dc.identifier.wosWOS:000249791700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal of Assisted Reproduction and Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPAI-1 geneen_US
dc.subjectTPA geneen_US
dc.subjectpolycystic ovary syndromeen_US
dc.title4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndromeen_US
dc.typeArticleen_US

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