Levothyroxine absorption test results in patients with TSH elevation resistant to treatment

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dc.contributor.authorSimsir, Ilgin Yildirim
dc.contributor.authorSoyaltin, Utku Erdem
dc.contributor.authorOzgen, Ahmet Gokhan
dc.date.accessioned2019-10-27T09:45:10Z
dc.date.available2019-10-27T09:45:10Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction Persistent elevation of thyroid-stimulating hormone (TSH) is common in endocrinology practice in patients undergoing replacement or suppression therapy with levothyroxine sodium (LT4). After examining the causes of this condition, LT4 absorption test is recommended. In this report, we wanted to share our results of LT4 absorption test in patients with elevated TSH levels. Materials-methods The files of patients who presented to our clinic between 2015 and 2018, whose TSH elevation continued despite high-dose LT4 therapy, and who underwent absorption test were reviewed retrospectively. Results Levothyroxine sodium absorption test was applied to five patients. Absorption test revealed LT4 malabsorption in two patients and pseudomalabsorption in the other three patients. Discussion When all published pseudomalabsorption cases were considered, it has been stated that at least 2.5 times increase in basal fT4 level may exclude malabsorption. The formula we used has been implemented by Cleveland Clinic since 2014. Conclusion In cases where TSH normalization is not achieved despite high doses of LT4 therapy, LT4 absorption test is an easy test for administration and interpretation and prevents unnecessary medical treatments and examinations.en_US
dc.identifier.doi10.1007/s12020-019-01889-xen_US
dc.identifier.endpage121en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue1en_US
dc.identifier.pmid30868414en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-019-01889-x
dc.identifier.urihttps://hdl.handle.net/11454/29105
dc.identifier.volume64en_US
dc.identifier.wosWOS:000463986100014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLevothyroxineen_US
dc.subjectMalabsorptionen_US
dc.subjectPseudomalabsorptionen_US
dc.titleLevothyroxine absorption test results in patients with TSH elevation resistant to treatmenten_US
dc.typeArticleen_US

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