Genetic polymorphisms of inflammatory response gene TNF-alpha and its influence on sporadic pancreatic neuroendocrine tumors predisposition risk

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dc.contributor.authorKarakaxas, Dimitrios
dc.contributor.authorGazouli, Maria
dc.contributor.authorCoker, Ahmet
dc.contributor.authorAgalianos, Christos
dc.contributor.authorPapanikolaou, Ioannis S.
dc.contributor.authorPatapis, Pavlos
dc.contributor.authorLiakakos, Theodoros
dc.contributor.authorDervenis, Christos
dc.date.accessioned2019-10-27T22:12:57Z
dc.date.available2019-10-27T22:12:57Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractThe diagnosed incidence of pancreatic neuroendocrine tumors (pNETs) is increasing; however, their etiology remains poorly understood. PNETs are a rare, heterogeneous group of tumors arising from the endocrine cells of the pancreas, and genetic risk factors for sporadic pNETs are inadequately understood. It is known that pNETs secrete biogenic amines, hormones and growth factors, tumor necrosis factor-alpha (TNF-alpha) being one of them. Furthermore, cytokines and other proinflammatory mediators have been implicated in inflammatory pancreatic diseases including pancreatitis and cancer. The aim of our study was to analyze TNF-alpha promoter gene polymorphisms as risk factors for pNETs using germline DNA collected in a population-based case-control study of pancreatic cancer [42 pNET cases, 78 pancreatic ductal adenocarcinoma (PDAC) cases, 17 intraductal papillary mucinous neoplasm (IPMN) and 98 healthy controls] conducted in the Athens, Greece and Izmir, Turkey areas. For subsequent analysis, we excluded cases and controls with known genetic syndromes. The CC genotype at the -1031 position was more frequent in pNET and IPMN patients (p = 0.0002 and p = 0.009, respectively), suggesting its possible role in pNET development. Furthermore, the AA genotype at the -308 position was overrepresented in IPMN cases (p = 0.03), and AA genotype at the -238 position was more frequent in PDAC cases (p = 0.03) compared to healthy individuals. With regard to tumor characteristics, no statistically significant association was detected. Our findings suggest the putative role of TNF-alpha -1031 polymorphism in the development of pNET and IPMN, whereas the -308 polymorphism seems to be overrepresented among IPMN cases and -238 polymorphism among PDAC cases.en_US
dc.identifier.doi10.1007/s12032-014-0241-zen_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue10en_US
dc.identifier.pmid25213764en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-014-0241-z
dc.identifier.urihttps://hdl.handle.net/11454/49652
dc.identifier.volume31en_US
dc.identifier.wosWOS:000342079600054en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTNF-alphaen_US
dc.subjectPancreatic canceren_US
dc.subjectpNETen_US
dc.subjectIPMNen_US
dc.subjectPDACen_US
dc.titleGenetic polymorphisms of inflammatory response gene TNF-alpha and its influence on sporadic pancreatic neuroendocrine tumors predisposition risken_US
dc.typeArticleen_US

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