Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events

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dc.contributor.authorde Kleijn, Dominique P. V.
dc.contributor.authorMoll, Frans L.
dc.contributor.authorHellings, Willem E.
dc.contributor.authorOzsarlak-Sozer, Gonen
dc.contributor.authorde Bruin, Peter
dc.contributor.authorDoevendans, Pieter A.
dc.contributor.authorVink, Aryan
dc.contributor.authorCatanzariti, Louise M.
dc.contributor.authorSchoneveld, Arjan H.
dc.contributor.authorAlgra, Ale
dc.contributor.authorDaemen, Mat J.
dc.contributor.authorBiessen, E. A.
dc.contributor.authorde Jager, W.
dc.contributor.authorZhang, Huoming
dc.contributor.authorde Vries, Jean-Paul
dc.contributor.authorFalk, Erling
dc.contributor.authorLim, Sai K.
dc.contributor.authorvan der Spek, Peter J.
dc.contributor.authorSze, Siu Kwan
dc.contributor.authorPasterkamp, Gerard
dc.date.accessioned2019-10-27T21:18:39Z
dc.date.available2019-10-27T21:18:39Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective-Atherosclerotic cardiovascular disease is a major burden to health care. Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territories. Methods and Results-AtheroExpress is a biobank collecting atherosclerotic lesions during surgery, with a 3-year follow-up. The composite primary outcome encompasses all cardiovascular events and interventions, eg, cardiovascular death, myocardial infarction, stroke, and endovascular interventions. A proteomics search identified osteopontin as a potential plaque biomarker. Patients undergoing carotid surgery (n=574) served as the cohort in which plaque osteopontin levels were examined in relation to their outcome during follow-up and was validated in a cohort of patients undergoing femoral endarterectomy (n=151). Comparing the highest quartile of carotid plaque osteopontin levels with quartile 1 showed a hazard ratio for the primary outcome of 3.8 (95% confidence interval, 2.6-5.9). The outcome did not change after adjustment for plaque characteristics and traditional risk factors (hazard ratio, 3.5; 95% confidence interval, 2.0-5.9). The femoral validation cohort showed a hazard ratio of 3.8 (95% confidence interval 2.0 to 7.4) comparing osteopontin levels in quartile 4 with quartile 1. Conclusion-Plaque osteopontin levels in single lesions are predictive for cardiovascular events in other vascular territories. Local atherosclerotic plaques are a source of prognostic biomarkers with a high predictive value for secondary manifestations of atherosclerotic disease. (Arterioscler Thromb Vasc Biol. 2010;30:612-619.)en_US
dc.description.sponsorshipEUEuropean Union (EU) [FP6-2004-Mobility-6 021773, FP6-037400 Immunath-2006]; Ministry of Education of SingaporeMinistry of Education, Singapore [ARC: T206B3211]; UMCU strategic Investment Preventionen_US
dc.description.sponsorshipEU FP6-2004-Mobility-6 # 021773 (D.d.K.), Ministry of Education of Singapore (ARC: T206B3211 to S. K. S.), EU FP6-037400 Immunath-2006 (to D.d.K. and G. P.), and the UMCU strategic Investment Prevention (to G. P.).en_US
dc.identifier.doi10.1161/ATVBAHA.109.194944en_US
dc.identifier.endpageU486en_US
dc.identifier.issn1079-5642
dc.identifier.issue3en_US
dc.identifier.pmid20018935en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage612en_US
dc.identifier.urihttps://doi.org/10.1161/ATVBAHA.109.194944
dc.identifier.urihttps://hdl.handle.net/11454/44020
dc.identifier.volume30en_US
dc.identifier.wosWOS:000274658700038en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofArteriosclerosis Thrombosis and Vascular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectarterectomyen_US
dc.subjectatherosclerosisen_US
dc.subjectbiomarkeren_US
dc.subjectplaqueen_US
dc.titleLocal Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Eventsen_US
dc.typeArticleen_US

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