CAR T Cells: Cancer Cell Surface Receptors Are the Target for Cancer Therapy
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tabriz Univ Medical Sciences & Health Services
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Immunotherapy has become a prominent strategy for the treatment of cancer. A method that improves the immune system's ability to attack a tumor (Enhances antigen binding). Targeted killing of malignant cells by adoptive transfer of chimeric antigen receptor (CAR) T cells is a promising immunotherapy technique in the treatment of cancers. For this purpose, the patient's immune cells, with genetic engineering aid, are loaded with chimeric receptors that have particular antigen binding and activate cytotoxic T lymphocytes. That increases the effectiveness of immune cells and destroying cancer cells. This review discusses the basic structure and function of CAR-T cells and how antigenic targets are identified to treat different cancers and address the disadvantages of this treatment for cancer.
Açıklama
Anahtar Kelimeler
CAR-T cell, Immunotherapy, Surface receptors, Tumor microenvironment, Chimeric-Antigen-Receptor, Acute Myeloid-Leukemia, Antitumor-Activity, Stem-Cells, Cd19 Car, Immunotherapy, Mesothelin, Chemotherapy, Malignancies, Persistence
Kaynak
Advanced Pharmaceutical Bulletin
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
12
Sayı
3
