Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake

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dc.authoridKımız Geboloğlu, Ilgın/0000-0002-9639-6550
dc.authorscopusid57204290601
dc.authorscopusid23995769500
dc.authorwosidKımız Geboloğlu, Ilgın/CAG-4566-2022
dc.contributor.authorKimiz-Gebologlu, Ilgin
dc.contributor.authorOncel, Suphi S.
dc.date.accessioned2023-01-12T19:55:12Z
dc.date.available2023-01-12T19:55:12Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractExosomes are nanovesicles with different contents that play a role in various biological and pathological processes. It offers significant advantages over other delivery systems such as liposomes and polymeric nanoparticles. Although exosomes are expected to be effective therapeutic agents, their optimal use remains a challenge. The development of methods for large-scale production, isolation, and drug loading is necessary to improve their efficiency and therapeutic potential. In this review, after mentioning general properties and biological functions of the exosomes, details of their potential for use in the drug delivery system are presented. For this purpose, methodologies for the large-scale production of exosomes, exosome isolation, exosomal cargo loading, and exosome uptake by the recipient cell are reviewed. The current challenges and potential directions of this new area of drug delivery that has become popular recently are also investigated.en_US
dc.description.sponsorshipEge Univer-sity Scientific Research Projects Coordination Unit [22868]en_US
dc.description.sponsorshipAcknowledgments This work was supported through research grants from Ege Univer-sity Scientific Research Projects Coordination Unit with a project num-ber of 22868.en_US
dc.identifier.doi10.1016/j.jconrel.2022.05.027
dc.identifier.endpage543en_US
dc.identifier.issn0168-3659
dc.identifier.issn1873-4995
dc.identifier.pmid35597405en_US
dc.identifier.scopus2-s2.0-85130561687en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage533en_US
dc.identifier.urihttps://doi.org/10.1016/j.jconrel.2022.05.027
dc.identifier.urihttps://hdl.handle.net/11454/76632
dc.identifier.volume347en_US
dc.identifier.wosWOS:000808573800002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Controlled Releaseen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExosomesen_US
dc.subjectDrug deliveryen_US
dc.subjectLarge-scale productionen_US
dc.subjectExosome isolationen_US
dc.subjectExosome loading efficiencyen_US
dc.subjectExosome uptakeen_US
dc.subjectExtracellular Vesiclesen_US
dc.subjectDeliveryen_US
dc.subjectTherapeuticsen_US
dc.subjectProgressen_US
dc.subjectTherapyen_US
dc.subjectBiogenesisen_US
dc.subjectSecretionen_US
dc.subjectSystemsen_US
dc.titleExosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptakeen_US
dc.typeReviewen_US

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