Pregnancy-associated plasma protein A gene polymorphism in pregnant women with preeclampsia and intrauterine growth restriction

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dc.contributor.authorOzkan S.
dc.contributor.authorSanhal C.Y.
dc.contributor.authorYeniel O.
dc.contributor.authorArslan Ates E.
dc.contributor.authorErgenoglu M.
dc.contributor.authorBinbir B.
dc.contributor.authorOnay H.
dc.contributor.authorÖzkınay F.
dc.contributor.authorSagol S.
dc.date.accessioned2019-10-26T21:24:39Z
dc.date.available2019-10-26T21:24:39Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractPreeclampsia (PE) and intrauterine growth restriction (IUGR) are still among the most commonly researched titles in perinatology. To shed light on their etiology, new prevention and treatment strategies are the major targets of studies. In this study, we aimed to investigate the relation between gene polymorphism of one of the products of trophoblasts, pregnancy-associated plasma protein A (PAPP-A) and PE/IUGR.A total of 147 women (IUGR, n = 61; PE, n = 47; IUGR + PE, n = 37; eclampsia, n = 2) were compared with 103 controls with respect to the sequencing of exon 14 of the PAPP-A gene to detect (rs7020782) polymorphism. Genotypes "AA" and "CC" were given in the event of A or C allele homozygosity and "AC" in A and C allele heterozygosity. Our findings revealed that the rate of AA, CC homozygotes, and AC heterozygotes did not differ between groups. Moreover, there was no difference in the distribution of PAPP-A genotypes among the patients with IUGR, PE, IUGR + PE, or eclampsia. Finally, birth weight, rate of the presence of proteinuria, and total protein excretion on 24-hour urine were similar in the subgroups of AA, AC, and CC genotypes in the study group. Our study demonstrated no association between PAPP-A gene rs7020782 polymorphism and PE/IUGR. © 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the Research Foundation of Ege University. --en_US
dc.identifier.doi10.1016/j.kjms.2015.08.005en_US
dc.identifier.endpage522en_US
dc.identifier.issn1607-551X
dc.identifier.issue10en_US
dc.identifier.pmid26520690en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage518en_US
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2015.08.005
dc.identifier.urihttps://hdl.handle.net/11454/17187
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier (Singapore) Pte Ltden_US
dc.relation.ispartofKaohsiung Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeneen_US
dc.subjectIntrauterine growth restrictionen_US
dc.subjectPAPP-Aen_US
dc.subjectPolymorphismen_US
dc.subjectPreeclampsiaen_US
dc.titlePregnancy-associated plasma protein A gene polymorphism in pregnant women with preeclampsia and intrauterine growth restrictionen_US
dc.typeArticleen_US

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