The relationship between levels of plasma homocysteine and presence of coronary artery disease and endothelial dysfunction in type II diabetic patients [Tip II diyabetik hastalarda plazma homosistein düzeyleri ile koroner arter hastaligi ve endotel disfonksiyonu varligi arasindaki i·lişki]

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dc.contributor.authorAliyev E.
dc.contributor.authorTengiz I.
dc.contributor.authorErcan E.
dc.contributor.authorŞekuri C.
dc.contributor.authorTümüklü M.
dc.contributor.authorAkin M.
dc.contributor.authorNalbantgil I.
dc.date.accessioned2019-10-27T00:12:03Z
dc.date.available2019-10-27T00:12:03Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The causal relationship between hyper-homocysteinemia and cardiovascular morbidity and mortality is not clear. In this study, the relationship between levels of plasma homocysteine and the presence of coronary artery disease and endothelial dysfunction in type II diabetic patients was evaluated. Material and Methods: The study group consisted of 50 type II diabetic patients who underwent exercise stress testing or thallium-201 myocardial perfusion imaging for the diagnosis of CAD. The study group was divided into two groups according to myocardial ischemic signs and angiographic findings: Group I (n= 25), patients with CAD or Group II (n= 25), patients without CAD. Plasma homocysteine levels were compared among these groups. In addition, the study population was divided into two groups according to their plasma homocysteine levels: Group H (n= 23), patients with hyper-homocysteinemia or Group N (n= 27), patients with normo-homocysteinemia. Flow-mediated dilatation (FMD) and nitrate-induced dilatation (NID) as markers of the endothelial functions were compared among these different groups. Results: Male gender was dominant in Group I and patients with hyper-homocysteinemia. Other clinical features such as lipid profiles, haemoglobin A1c, fibrinolytic and inflammatory activation markers did not different among the groups. Plasma homocysteine levels were significantly higher in Group I than in Group II (16.4 ± 5.1 and 9.2 ± 2.2 mmol/L, respectively; p< 0.0001). In the second analysis evaluating the effect of hyper-homocysteinemia on endothelial function, determinations of FMD and NID were similar in Groups H and N. Conclusion: Our findings show what appears to be a synergistic contribution of hyper-homocysteinemia on the development of CAD in type II diabetic patients. The detection of hyper-homocysteinemia may be important for the prediction of risk in diabetic patients. In addition, it may provide new approaches for primary and secondary prevention. Copyright © 2005 by Türkiye Klinikleri.en_US
dc.identifier.endpage616en_US
dc.identifier.issn1300-0292
dc.identifier.issn1300-0292en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage609en_US
dc.identifier.urihttps://hdl.handle.net/11454/22276
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary arteriosclerosisen_US
dc.subjectDiabetes mellitusen_US
dc.subjectHomocysteineen_US
dc.titleThe relationship between levels of plasma homocysteine and presence of coronary artery disease and endothelial dysfunction in type II diabetic patients [Tip II diyabetik hastalarda plazma homosistein düzeyleri ile koroner arter hastaligi ve endotel disfonksiyonu varligi arasindaki i·lişki]en_US
dc.typeArticleen_US

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