The relationship between levels of plasma homocysteine and presence of coronary artery disease and endothelial dysfunction in type II diabetic patients [Tip II diyabetik hastalarda plazma homosistein düzeyleri ile koroner arter hastaligi ve endotel disfonksiyonu varligi arasindaki i·lişki]
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The causal relationship between hyper-homocysteinemia and cardiovascular morbidity and mortality is not clear. In this study, the relationship between levels of plasma homocysteine and the presence of coronary artery disease and endothelial dysfunction in type II diabetic patients was evaluated. Material and Methods: The study group consisted of 50 type II diabetic patients who underwent exercise stress testing or thallium-201 myocardial perfusion imaging for the diagnosis of CAD. The study group was divided into two groups according to myocardial ischemic signs and angiographic findings: Group I (n= 25), patients with CAD or Group II (n= 25), patients without CAD. Plasma homocysteine levels were compared among these groups. In addition, the study population was divided into two groups according to their plasma homocysteine levels: Group H (n= 23), patients with hyper-homocysteinemia or Group N (n= 27), patients with normo-homocysteinemia. Flow-mediated dilatation (FMD) and nitrate-induced dilatation (NID) as markers of the endothelial functions were compared among these different groups. Results: Male gender was dominant in Group I and patients with hyper-homocysteinemia. Other clinical features such as lipid profiles, haemoglobin A1c, fibrinolytic and inflammatory activation markers did not different among the groups. Plasma homocysteine levels were significantly higher in Group I than in Group II (16.4 ± 5.1 and 9.2 ± 2.2 mmol/L, respectively; p< 0.0001). In the second analysis evaluating the effect of hyper-homocysteinemia on endothelial function, determinations of FMD and NID were similar in Groups H and N. Conclusion: Our findings show what appears to be a synergistic contribution of hyper-homocysteinemia on the development of CAD in type II diabetic patients. The detection of hyper-homocysteinemia may be important for the prediction of risk in diabetic patients. In addition, it may provide new approaches for primary and secondary prevention. Copyright © 2005 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Coronary arteriosclerosis, Diabetes mellitus, Homocysteine
Kaynak
Turkiye Klinikleri Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
25
Sayı
5
