Thermogenic response and leptin levels rise after recovery of the euthyroid state

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dc.contributor.authorSarac, F.
dc.contributor.authorOezgen, A. Goekhan
dc.contributor.authorCelebi, G.
dc.contributor.authorPehlivan, M.
dc.contributor.authorUluer, H.
dc.contributor.authorYilmaz, C.
dc.date.accessioned2019-10-27T21:18:22Z
dc.date.available2019-10-27T21:18:22Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aims of the study were to compare: a) the thermogenic responses in subclinical hypothyroidism (SH) and euthyroid state; b) the relationship between thermogenic response and leptin level. Methods: Thirty women diagnosed with SH (mean age 39.9+/-4.1 yr; body mass index 23.2+/-2.5 kg/m(2)) were enrolled in the study. Thyroid function tests, leptin, and lipid profiles were measured during SH and after stable euthyroidism was recovered. Thermogenic response was measured by Water Immersion Calorimetry during SR and after the euthyroid state was attained. Results: The mean level of thermogenic response was found to be 1.45+/-0.43 kcal/kg.h in women with SR. It changed to 1.54+/-0.77 kcal/kg.h (p=0.01) in the euthyroid state; the change was statistically significant. Mean level of leptin was found to be 7.22+/-2.6 ng/ml in SH; and 15.8+/-8.0 ng/ml in the euthyroid state. There was a positive correlation between leptin and free T(3) (r=0.460, p=0.009) levels in SH. There were positive correlations between leptin level and fat mass in SH (r=0.820, p=0.01) and in the euthyroid state (r=0.700, p=0.03). Conclusions: No correlations were found between thermogenic response and leptin levels in SH and in the euthyroid state. Thermogenic response and leptin levels rose after the euthyroid state was recovered. (J. Endocrinol. Invest. 33: 254-257, 2010) (C) 2010, Editrice Kurtisen_US
dc.identifier.doi10.3275/6566en_US
dc.identifier.endpage257en_US
dc.identifier.issn0391-4097
dc.identifier.issue4en_US
dc.identifier.pmid19834316en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage254en_US
dc.identifier.urihttps://doi.org/10.3275/6566
dc.identifier.urihttps://hdl.handle.net/11454/43971
dc.identifier.volume33en_US
dc.identifier.wosWOS:000278570700010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeptinen_US
dc.subjectsubclinical hypothyroidismen_US
dc.subjectthermogenic responseen_US
dc.titleThermogenic response and leptin levels rise after recovery of the euthyroid stateen_US
dc.typeArticleen_US

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