The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions

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dc.authoridBay, Veysel/0000-0002-9339-4840
dc.authoridBanos, Georgios/0000-0002-7674-858X
dc.authoridSanchez-Molano, Enrique/0000-0003-2734-8560
dc.authoridEvans, Nicholas/0000-0002-2950-1007
dc.authorscopusid58054638200
dc.authorscopusid55884671000
dc.authorscopusid56114176300
dc.authorscopusid56820881500
dc.authorscopusid58054673700
dc.authorscopusid56872686500
dc.authorscopusid57197874669
dc.authorwosidBarden, Matthew/ACK-6542-2022
dc.authorwosidBay, Veysel/AAD-6135-2019
dc.contributor.authorBay, V
dc.contributor.authorGillespie, A.
dc.contributor.authorGanda, E.
dc.contributor.authorEvans, N. J.
dc.contributor.authorCarter, S. D.
dc.contributor.authorLenzi, L.
dc.contributor.authorLucaci, A.
dc.date.accessioned2024-08-25T18:48:13Z
dc.date.available2024-08-25T18:48:13Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. We describe herein the bovine foot skin microbiota and its associations with BDD using 16S rRNA gene amplicon and shotgun metagenomic sequencing on samples from 259 dairy cows from three UK dairy farms. Results We show evidence of dysbiosis, and differences in taxonomy and functional profiles in the bovine foot skin microbiome of clinically healthy animals that subsequently develop BDD lesions, compared to those that do not. Our results suggest that taxonomical and functional differences together with alterations in ecological interactions between bacteria in the normal foot skin microbiome may predispose an animal to develop BDD lesions. Using genome-wide association and regional heritability mapping approaches, we provide first evidence for interactions between host genotype and certain members of the foot skin microbiota. We show the existence of significant genetic variation in the relative abundance of Treponema spp. and Peptoclostridium spp. and identify regions in the bovine genome that explain a significant proportion of this variation. Conclusions Collectively this work shows early changes in taxonomic and functional profiles of the bovine foot skin microbiota in clinically healthy animals which are associated with subsequent development of BDD and could be relevant to prevention of disease. The description of host genetic control of members of the foot skin microbiota, combined with the association of the latter with BDD development offer new insights into a complex relationship that can be exploited in selective breeding programmes.en_US
dc.description.sponsorshipAcademy of Medical Sciences; Technology Directorate Strategy Group, University of Liverpoolen_US
dc.description.sponsorshipThis study was funded by the Academy of Medical Sciences. Work conducted at the Centre for Genomic Research was part-funded by the Technology Directorate Strategy Group, University of Liverpool.en_US
dc.identifier.doi10.1186/s40168-022-01440-7
dc.identifier.issn2049-2618
dc.identifier.issue1en_US
dc.identifier.pmid36624507en_US
dc.identifier.scopus2-s2.0-85145956856en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s40168-022-01440-7
dc.identifier.urihttps://hdl.handle.net/11454/102192
dc.identifier.volume11en_US
dc.identifier.wosWOS:000911670000002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofMicrobiomeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectDairyen_US
dc.subjectIdentificationen_US
dc.subjectExpressionen_US
dc.subjectDiversityen_US
dc.subjectMutationen_US
dc.subjectDiseaseen_US
dc.subjectZnf750en_US
dc.subjectGenesen_US
dc.titleThe bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesionsen_US
dc.typeArticleen_US

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