Ant-2 Glycoprotein I Antibodies in Children with Rheumatologic Disorders

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dc.contributor.authorAzarsiz, Elif
dc.contributor.authorEman, Gamze
dc.contributor.authorAkarcan, Sanem Eren
dc.contributor.authorSevercan, Ezgi Ulusoy
dc.contributor.authorKaraca, Neslihan
dc.contributor.authorAksu, Guzide
dc.contributor.authorKutukculer, Necil
dc.date.accessioned2019-10-27T09:59:14Z
dc.date.available2019-10-27T09:59:14Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractAnti-beta-2-glycoprotein I antibodies (anti-2GPI) which are the main antiphospholipid antibodies that characterize the autoimmune antiphospholipid syndrome are pathogenic and are contributing to thrombosis. We aimed to evaluate the presence and the diagnostic importance of these antibodies in children with different rheumatologic diseases with or without thrombosis risk. A total of 100 children with different rheumatologic diseases evaluated retrospectively. The mean anti-2GPI IgG (p=0.108), IgA (p=0.547), and IgM (p=0.807) levels showed no statistically significant difference between different diagnosis groups. But anti-2GPI IgA and IgM levels were higher in SLE patient group. The mean anti-2GPI IgG (p=0.375), IgA (p=0.811), and IgM (p=0.276) levels were not also showed difference between disease groups with/without predisposition to thrombosis even though concentrations were higher in thrombosis group. In children with rheumatological complaints, anti-2GPI antibody measurements should not be the first diagnostic criteria if vasculitis is not thought as the primary defect underlying the clinical symptoms.en_US
dc.identifier.doi10.1007/s12291-017-0711-0en_US
dc.identifier.endpage100en_US
dc.identifier.issn0970-1915
dc.identifier.issn0974-0422
dc.identifier.issue1en_US
dc.identifier.pmid30728679en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://doi.org/10.1007/s12291-017-0711-0
dc.identifier.urihttps://hdl.handle.net/11454/29587
dc.identifier.volume34en_US
dc.identifier.wosWOS:000456572200013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Clinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-2GPIen_US
dc.subjectAutoimmunityen_US
dc.subjectRheumatological disorderen_US
dc.subjectThrombosisen_US
dc.titleAnt-2 Glycoprotein I Antibodies in Children with Rheumatologic Disordersen_US
dc.typeArticleen_US

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