Premature luteinization defined as progesterone estradiol ratio >1 on hCG administration day seems to adversely affect clinical outcome in long gonadotropin-releasing hormone agonist cycles

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dc.contributor.authorÖzçakir H.T.
dc.contributor.authorLevi R.
dc.contributor.authorTavmergen E.
dc.contributor.authorGöker E.N.T.
dc.date.accessioned2019-10-27T08:59:28Z
dc.date.available2019-10-27T08:59:28Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: To examine the effect of premature luteinization on the outcomes in long gonadotropin-releasing hormone agonist cycles. Methods: Two-hundred and forty-eight patients who had undergone assisted reproductive technology for infertility treatment between 2001 and 2002 were enrolled into the study. The patients were separated into two groups according to P/E2 ratios on human chorionic gonadotropin administration day. Group A consisted of the patients whose P/E2 ratio was 1 (n = 116) and Group B consisted of the patients with premature luteinization of which P/E2 ratio was > 1 (n = 132). The P/E2 ratio calculation was performed as follows: P (in ng/mL) × †1,000/E2 (in pg/mL). The primary outcome measures included oocyte quality, fertilization rates and clinical pregnancy rates. Results: The mean number of mature oocytes retrieved in the groups were 9.5 ± 4.8 and 6.4 ± 3.6, respectively, and the difference was statistically significant (P < 0.05). Although the difference between the fertilization rates in Group A and Group B was not statistically significant (P > 0.05), the clinical pregnancy rates seemed to be affected adversely in the Group B patients with premature luteinization (41.4% versus 28%, respectively; P < 0.05). Conclusion: Premature luteinization, defined as P/E2 > 1 on human chorionic gonadotropin administration day, in long gonadotropin-releasing hormone agonist cycles seems to adversely affect clinical outcome.en_US
dc.identifier.doi10.1111/j.1447-0756.2003.00166.xen_US
dc.identifier.endpage104en_US
dc.identifier.issn1341-8076
dc.identifier.issue2en_US
dc.identifier.pmid15009611en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2003.00166.x
dc.identifier.urihttps://hdl.handle.net/11454/27813
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClinical outcomesen_US
dc.subjectLong GnRH-a cyclesen_US
dc.subjectPremature luteinizationen_US
dc.titlePremature luteinization defined as progesterone estradiol ratio >1 on hCG administration day seems to adversely affect clinical outcome in long gonadotropin-releasing hormone agonist cyclesen_US
dc.typeArticleen_US

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