Evaluation bone uptake of alendronate sodium via vaginal route by gamma scintigraphy, Vaginal uptake of alendronate sodium

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dc.contributor.authorIlem-Ozdemir, D.
dc.contributor.authorAsikoglu, M.
dc.contributor.authorGuneri, T.
dc.contributor.authorKoseoglu, K.
dc.contributor.authorOzkilic, H.
dc.date.accessioned2019-10-27T22:05:48Z
dc.date.available2019-10-27T22:05:48Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractAlendronate sodium (ALD) is a second generation amino bisphosphonate that use for treatment of bone diseases. Since ALD is poorly absorbed from the gastrointestinal tract and its absorption is markedly reduced by food, the aim of this study is to evaluate the bone uptake of ALD through vaginal route. To evaluate the bone uptake of ALD by gamma scintigraphy. ALD was radiolabeled with Technetium-99m (Tc-99m). Vaginal suppositories and injectable solution of Tc-99m-ALD was prepared and gamma scintigraphy studies were performed with intravaginally and intravenously Tc-99m-ALD applied rabbits. The results were revealed that ALD was successfully labeled with Tc-99m. After intra vaginal and intravenous application, Tc-99m-ALD showed a high uptake in bone. Despite accumulation times and uptake ratios showed differences between administration routes, our preliminary observations suggest that the intravaginal route appears to be a viable alternative for ALD application and should be evaluated in future clinical studies.en_US
dc.description.sponsorshipEge UniversityEge University [08ECZ015]en_US
dc.description.sponsorshipThis study was supported by Ege University Research Found (08ECZ015). The authors thank to Ege University Nuclear Medicine Department technicians for their technical assistance for the animal experiments.en_US
dc.identifier.doi10.1016/S1773-2247(14)50035-4
dc.identifier.endpage221en_US
dc.identifier.issn1773-2247
dc.identifier.issn1773-2247en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage218en_US
dc.identifier.urihttps://doi.org/10.1016/S1773-2247(14)50035-4
dc.identifier.urihttps://hdl.handle.net/11454/48604
dc.identifier.volume24en_US
dc.identifier.wosWOS:000339928800015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlendronate sodiumen_US
dc.subjectBone uptakeen_US
dc.subjectGamma scintigraphyen_US
dc.subjectIntravaginal applicationen_US
dc.subjectTechnetium-99men_US
dc.titleEvaluation bone uptake of alendronate sodium via vaginal route by gamma scintigraphy, Vaginal uptake of alendronate sodiumen_US
dc.typeArticleen_US

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