Evaluation bone uptake of alendronate sodium via vaginal route by gamma scintigraphy, Vaginal uptake of alendronate sodium

Küçük Resim Yok

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Elsevier Science Bv

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Alendronate sodium (ALD) is a second generation amino bisphosphonate that use for treatment of bone diseases. Since ALD is poorly absorbed from the gastrointestinal tract and its absorption is markedly reduced by food, the aim of this study is to evaluate the bone uptake of ALD through vaginal route. To evaluate the bone uptake of ALD by gamma scintigraphy. ALD was radiolabeled with Technetium-99m (Tc-99m). Vaginal suppositories and injectable solution of Tc-99m-ALD was prepared and gamma scintigraphy studies were performed with intravaginally and intravenously Tc-99m-ALD applied rabbits. The results were revealed that ALD was successfully labeled with Tc-99m. After intra vaginal and intravenous application, Tc-99m-ALD showed a high uptake in bone. Despite accumulation times and uptake ratios showed differences between administration routes, our preliminary observations suggest that the intravaginal route appears to be a viable alternative for ALD application and should be evaluated in future clinical studies.

Açıklama

Anahtar Kelimeler

Alendronate sodium, Bone uptake, Gamma scintigraphy, Intravaginal application, Technetium-99m

Kaynak

Journal of Drug Delivery Science and Technology

WoS Q Değeri

Q4

Scopus Q Değeri

Q1

Cilt

24

Sayı

2

Künye