Deneysel sepsiste C-reaktif protein (CRP) prokalsitonin (PCT) lökosit ve laktat düzeylerinin değişimi
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Dosyalar
Tarih
2018
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Yayıncı
Ege Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Enfeksiyona verilen sistemik inflamatuvar yanıt olarak tanımlanan “sepsis” tedavideki ilerlemelere rağmen, şok ve multiorgan sistem yetmezliği ile komplike olduğunda yüksek mortaliteye sahip bir tablodur. Çalışmamızda 250gr ağırlığında 25 adet erkek Sprague-Dawley türü erişkin ratlar 3 gruba ayrıldı. Grup 1: Sepsis Grubu:(n= 10) 20 gauge iğne ile perforasyon, Grup 2: Ağır Sepsis Grubu: (n= 10) Çekal insizyon, Grup 3: Sham Grubu: (n= 5) Laparotomi sonrası çekum perforasyonu yada insizyonu yapılmadan barsak ve çekumun elle iritasyonu. Tüm gruplardaki ratların çalışmanın başında (0. Saat) ve 6. saatinde CRP, PCT, lökosit ve laktat düzeylerine bakıldı. Her üç grupta 0. ve 6. saatte bakılan PCT düzeyleri kıyaslandığında anlamlı artış tespit edildi. Lökosit ve CRP artışı sadece sepsis ve ağır sepsis gruplarında anlamlı bulunmuştur. Laktat düzeylerinde her üç grupta 0. ve 6. saatte anlamlı değişiklik saptanmadı. Çalışmamızda PCT, CRP ve lökosit düzeyindeki artışların sepsiste anlamlı olduğunu ve erken tanı ve tedavide önem arz ettiğini tespit ettik.
Sepsis, defined as a systemic inflammatory response to the infectious disease, was associated with high mortality when complicated with shock and multiorgan system insufficiency despite treatment. In the study, 25 male Sprague-Dawley male rats weighing 250gr were divided into 3 groups. Group 1: Sepsis Group: (n = 10) Perforated with 20 gauge needle, Group 2: Severe Sepsis Group: (n = 10) Cecal incision, Group 3: Sham Group: (n = 5) After laparotomy, graft perforation and manual irritation of intestine and cecum without incision. CRP, PCT, leucocyte and lactate levels were measured at the beginning of study (0. hour) and 6. hour in all groups of rats. A significant increase was detected in PCT levels between 0. and 6. hours in all three groups. Leukocyte and CRP increase was only found in sepsis and severe sepsis groups. No significant changes were detected in lactate levels in 0. and 6. hours in all three groups. We found that increases in PCT, CRP and leukocyte levels in our study were significant in sepsis and were important in early diagnosis and treatment.
Sepsis, defined as a systemic inflammatory response to the infectious disease, was associated with high mortality when complicated with shock and multiorgan system insufficiency despite treatment. In the study, 25 male Sprague-Dawley male rats weighing 250gr were divided into 3 groups. Group 1: Sepsis Group: (n = 10) Perforated with 20 gauge needle, Group 2: Severe Sepsis Group: (n = 10) Cecal incision, Group 3: Sham Group: (n = 5) After laparotomy, graft perforation and manual irritation of intestine and cecum without incision. CRP, PCT, leucocyte and lactate levels were measured at the beginning of study (0. hour) and 6. hour in all groups of rats. A significant increase was detected in PCT levels between 0. and 6. hours in all three groups. Leukocyte and CRP increase was only found in sepsis and severe sepsis groups. No significant changes were detected in lactate levels in 0. and 6. hours in all three groups. We found that increases in PCT, CRP and leukocyte levels in our study were significant in sepsis and were important in early diagnosis and treatment.
Açıklama
Anahtar Kelimeler
Sepsis, İnflamatuar Belirteçler, CRP, PCT, Lökosit, Laktat, Sepsis, Inflammatory Markers, CRP, PCT, Lactate, Leukocyte
