Anaplastic astroblastoma of childhood: aggressive behavior

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dc.contributor.authorKantar, M.
dc.contributor.authorErtan, Y.
dc.contributor.authorTurhan, T.
dc.contributor.authorKitis, O.
dc.contributor.authorAnacak, Y.
dc.contributor.authorAkalin, T.
dc.contributor.authorErsahin, Y.
dc.contributor.authorCetingul, N.
dc.date.accessioned2019-10-27T20:49:20Z
dc.date.available2019-10-27T20:49:20Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective Astroblastoma is an unusual brain tumor in childhood. Tumor usually arises from cerebral hemispheres. This large tumor is well-demarcated, lobulated, solid or cystic, and therefore, may resemble glioblastoma. Histopathologically, there are two types of astroblastoma: well-differentiated (low-grade) or anaplastic (high-grade). In low-grade astroblastoma, treatment of choice is complete excision. This type of tumor usually does not recur. However, anaplastic tumors can recur despite surgery, radiation, and chemotherapy and may be problematic for clinician. Case Report A 7-year-old female patient presented with an acute onset of vomiting and seizure. Magnetic resonance imaging study revealed a large mass in the left parietooccipital region. She underwent total excision of the tumor. Histopathologically, the tumor was an anaplastic astroblastoma. Her adjuvant treatment was planned to consist of radiation therapy and cisplatin-based chemotherapy. However, the tumor recurred early in the course, and she died 18 months after diagnosis. Conclusion High-grade astroblastomas behave like glioblastoma, as emphasized in this case report. Local control of this type of tumor seems difficult despite surgery, radiation therapy, and cisplatin-based chemotherapy.en_US
dc.identifier.doi10.1007/s00381-009-0885-8en_US
dc.identifier.endpage1129en_US
dc.identifier.issn0256-7040
dc.identifier.issn1433-0350
dc.identifier.issue9en_US
dc.identifier.pmid19357852en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1125en_US
dc.identifier.urihttps://doi.org/10.1007/s00381-009-0885-8
dc.identifier.urihttps://hdl.handle.net/11454/42858
dc.identifier.volume25en_US
dc.identifier.wosWOS:000268884200018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofChilds Nervous Systemen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstroblastomaen_US
dc.subjectChildrenen_US
dc.subjectSurgeryen_US
dc.subjectRadiation therapyen_US
dc.subjectChemotherapyen_US
dc.titleAnaplastic astroblastoma of childhood: aggressive behavioren_US
dc.typeArticleen_US

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