Acute acetaminophen nephrotoxicity and urinary gamma-glutamyl transferase activity in rats

Küçük Resim Yok

Tarih

1997

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Walter de Gruyter GmbH

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

In order to determine the relationship between the nephrotoxicity of acetaminophen and urinary gamma-glutamyl transferase (GGT) excretion, a single dose of 900 mg/kg acetaminophen (APAP) was administered to rats intraperitoneally. Following drug administration, 24 hour urine was collected and the kidneys were removed under ether anesthesia for histological examination. GGT activity measurements and quantitative analysis for creatinine was carried out on urine samples. Urinary GGT activity in the APAP administered group (n=12) (1.8 ± 0.21 U/mg creatinine) was significantly higher than in the control group (n=16) (0.77 ± 0.05 U/mg creatinine) (p<0.0002). Histological examination of the kidneys under light microscopy showed only very slight tissue damage. Further use of urinary GGT activity measurements in experimental nephrotoxicity studies has been suggested.

Açıklama

Anahtar Kelimeler

Acetaminophen, Gamma-glutamyl transferase, Nephrotoxicity

Kaynak

Drug Metabolism and Drug Interactions

WoS Q Değeri

Scopus Q Değeri

N/A

Cilt

14

Sayı

1

Künye