Preparation and evaluation of effect on Escherichia coli and Staphylococcus aureus of radiolabeled ampicillin-loaded graphene oxide nanoflakes

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dc.contributor.authorYurt, Fatma
dc.contributor.authorErsoz, Onur Alp
dc.contributor.authorHarputlu, Ersan
dc.contributor.authorOcakoglu, Kasim
dc.date.accessioned2019-10-27T10:05:42Z
dc.date.available2019-10-27T10:05:42Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractAmpicillin is a one of effective antibiotics against Gram-positive and Gram-negative bacteria. This study aimed to label ampicillin-loaded graphene oxide nanoflake (AMP-GO) with Tc-99m and evaluate of its in vitro binding to Staphylococcus aureus and Escherichia coli. Firstly, ampicillin was loaded into graphene oxide nanoflake prepared. AMP-GO was characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM) techniques, and the amount of loaded ampicillin onto GO was determined by UV-Vis absorption spectroscopy. AMP and AMP-GO were labeled with Tc-99m using stannous chloride reducing agent. Labeling efficiency of Tc-99m-AMP-GO was found to be 97.66 +/- 2.06%. Tc-99m-AMP-GO has higher binding efficiencies to both S. aureus and E.coli than Tc-99m-AMP. Tc-99m-AMP-GO could be promising candidate as agent infection nuclear imaging. Furthermore, in vivo studies of Tc-99m-AMP-GO with infected rats are planned to be performed.en_US
dc.identifier.doi10.1111/cbdd.13171en_US
dc.identifier.endpage1100en_US
dc.identifier.issn1747-0277
dc.identifier.issn1747-0285
dc.identifier.issue6en_US
dc.identifier.pmid29363273en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1094en_US
dc.identifier.urihttps://doi.org/10.1111/cbdd.13171
dc.identifier.urihttps://hdl.handle.net/11454/30382
dc.identifier.volume91en_US
dc.identifier.wosWOS:000431974400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofChemical Biology & Drug Designen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectampicillinen_US
dc.subjectdrug deliveryen_US
dc.subjectgraphene oxideen_US
dc.subjectin vitro uptakeen_US
dc.subjectradiolabeleden_US
dc.titlePreparation and evaluation of effect on Escherichia coli and Staphylococcus aureus of radiolabeled ampicillin-loaded graphene oxide nanoflakesen_US
dc.typeArticleen_US

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