Effect of direct plasma treatment and plasma-treated liquid on cutaneous squamous cell carcinoma: A proof-of-concept study

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dc.authoridErcan, Utku Kursat/0000-0002-9762-2265
dc.authoridOzdemir, Gizem Dilara/0000-0002-3682-3733
dc.authorscopusid57221564168
dc.authorscopusid39862855800
dc.authorscopusid55804374300
dc.authorscopusid55318033800
dc.authorwosidErcan, Utku Kursat/A-1658-2012
dc.authorwosidOzdemir, Gizem Dilara/AAR-4214-2020
dc.contributor.authorOzdemir, Gizem D. D.
dc.contributor.authorErcan, Utku K. K.
dc.contributor.authorKaraman, Ozan
dc.contributor.authorOltulu, Fatih
dc.date.accessioned2024-08-25T18:47:29Z
dc.date.available2024-08-25T18:47:29Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study investigates the efficacy of cold atmospheric plasma (CAP) in treating squamous cell carcinoma (SCC), a highly metastatic cancer. To assess the anticancer activity, two CAP treatment methods-direct treatment and indirect treatment (plasma-treated N-acetyl cysteine solution)-were used. Results indicate that both methods selectively target SCC cells, inducing oxidative and nitrosative stress, leading to decreased metabolic activity and increased apoptosis. Furthermore, a critical feature of cancer cells, metastatic behavior is also inhibited by CAP treatment. Coculture experiments demonstrate the effectiveness of CAP treatment in selectively inactivating SCC cells while leaving healthy cells unaffected. These findings suggest the potential use of CAP as a selective and effective treatment for SCC.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [SBAG-117S434]en_US
dc.description.sponsorshipACKNOWLEDGMENTS This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under the grant number of SBAG-117S434. The authors would like to thank Gunnur Pulat for her help in the thawing and proliferation of the cell lines.en_US
dc.identifier.doi10.1002/ppap.202200246
dc.identifier.issn1612-8850
dc.identifier.issn1612-8869
dc.identifier.scopus2-s2.0-85164491634en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/ppap.202200246
dc.identifier.urihttps://hdl.handle.net/11454/101922
dc.identifier.wosWOS:001019931500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofPlasma Processes and Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectcold plasmaen_US
dc.subjectdielectric barrier dischargesen_US
dc.subjectplasma medicineen_US
dc.subjectplasma-treated liquidsen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectCold Atmospheric Plasmaen_US
dc.subjectReactive Oxygenen_US
dc.subjectCancer-Treatmenten_US
dc.subjectCycle Arresten_US
dc.subjectApoptosisen_US
dc.subjectCavityen_US
dc.titleEffect of direct plasma treatment and plasma-treated liquid on cutaneous squamous cell carcinoma: A proof-of-concept studyen_US
dc.typeArticleen_US

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