Effect of direct plasma treatment and plasma-treated liquid on cutaneous squamous cell carcinoma: A proof-of-concept study
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study investigates the efficacy of cold atmospheric plasma (CAP) in treating squamous cell carcinoma (SCC), a highly metastatic cancer. To assess the anticancer activity, two CAP treatment methods-direct treatment and indirect treatment (plasma-treated N-acetyl cysteine solution)-were used. Results indicate that both methods selectively target SCC cells, inducing oxidative and nitrosative stress, leading to decreased metabolic activity and increased apoptosis. Furthermore, a critical feature of cancer cells, metastatic behavior is also inhibited by CAP treatment. Coculture experiments demonstrate the effectiveness of CAP treatment in selectively inactivating SCC cells while leaving healthy cells unaffected. These findings suggest the potential use of CAP as a selective and effective treatment for SCC.
Açıklama
Anahtar Kelimeler
cold plasma, dielectric barrier discharges, plasma medicine, plasma-treated liquids, squamous cell carcinoma, Cold Atmospheric Plasma, Reactive Oxygen, Cancer-Treatment, Cycle Arrest, Apoptosis, Cavity
Kaynak
Plasma Processes and Polymers
WoS Q Değeri
Q1
Scopus Q Değeri
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