Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae

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dc.contributor.authorSaleh, Hesham
dc.contributor.authorPetras, Daniel
dc.contributor.authorMainz, Andi
dc.contributor.authorKerwat, Dennis
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorErzurumlu, Yalcin
dc.contributor.authorSussmuth, Roderich D.
dc.date.accessioned2019-10-27T23:09:45Z
dc.date.available2019-10-27T23:09:45Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractA new para-aminobenzoic-acid-containing natural product from the mango pathogenic organism Xanthomonas citri pv. mangiferaeindicae is described. By means of stable isotope precursor feeding combined with nontargeted LC-MS/MS, the generated spectra were clustered and visualized in a molecular network. This led to the identification of a new member of the meroterpenoids, termed xanthomonic acid, which is composed of an isoprenylated Para-amino benzoic acid. In vitro cytotoxicity assays demonstrated activity of xanthomonic acid against several human cancer cell lines by induction of autophagy.en_US
dc.description.sponsorshipGerman Academic Exchange Service (Deutscher Akademischer Austauschdienst)Deutscher Akademischer Austausch Dienst (DAAD); Egyptian Ministry of Higher EducationScience and Technology Development Fund (STDF)en_US
dc.description.sponsorshipThe authors thank Dr. Sebastian Kemper (Technical University of Berlin) for the instrumentation of the NMR experiments and Dr. P. Ballar Kirmizibayrak (Ege University) for support and guidance on the autophagy study. H.S. thanks the collaborative funding and support from the German Academic Exchange Service (Deutscher Akademischer Austauschdienst) and the Egyptian Ministry of Higher Education.en_US
dc.identifier.doi10.1021/acs.jnatprod.5b01049en_US
dc.identifier.endpage1537en_US
dc.identifier.issn0163-3864
dc.identifier.issn1520-6025
dc.identifier.issue6en_US
dc.identifier.pmid27232656en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1532en_US
dc.identifier.urihttps://doi.org/10.1021/acs.jnatprod.5b01049
dc.identifier.urihttps://hdl.handle.net/11454/52738
dc.identifier.volume79en_US
dc.identifier.wosWOS:000378758200007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofJournal of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDeuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicaeen_US
dc.typeArticleen_US

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