PTPN22 gene polymorphism in Takayasu's arteritis

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dc.contributor.authorSahin N.
dc.contributor.authorAksu K.
dc.contributor.authorKamali S.
dc.contributor.authorBicakcigil M.
dc.contributor.authorÖzbalkan Z.
dc.contributor.authorFresko I.
dc.contributor.authorÖzer H.
dc.contributor.authorAkar S.
dc.contributor.authorOnat A.M.
dc.contributor.authorÇobankara V.
dc.contributor.authorKiraz S.
dc.contributor.authorÖztürk M.A.
dc.contributor.authorTunç E.
dc.contributor.authorYücel E.
dc.contributor.authorAteş A.
dc.contributor.authorKeser G.
dc.contributor.authorInanc M.
dc.contributor.authorDireskeneli H.
dc.contributor.authorSaruhan-Direskeneli G.
dc.date.accessioned2019-10-26T23:57:52Z
dc.date.available2019-10-26T23:57:52Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. Methods. Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with Xcm I enzyme. Results. Detected frequencies of heterozygous genotype (AG) were 5.1% (9/177) in control group and 3.8% (7/181) in TA group (P = 0.61, odds ratio: 0.75, 95% CI: 0.3, 2.0). No association with angiographic type, vascular involvement or prognosis of TA was observed either. Conclusion. The distribution of PTPN22 polymorphism did not reveal any association with TA in Turkey. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.en_US
dc.description.sponsorshipSAG-YYP/0007-15/01/ 2007 British Association for Psychopharmacologyen_US
dc.description.sponsorshipFunding: The study is supported by Marmara University Scientific Research Fund (BAPKO) (project no: SAG-YYP/0007-15/01/ 2007) and Istanbul University Research Fund (BAP). --en_US
dc.identifier.doi10.1093/rheumatology/ken106en_US
dc.identifier.endpage635en_US
dc.identifier.issn1462-0324
dc.identifier.issue5en_US
dc.identifier.pmid18375974en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage634en_US
dc.identifier.urihttps://doi.org/10.1093/rheumatology/ken106
dc.identifier.urihttps://hdl.handle.net/11454/21106
dc.identifier.volume47en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofRheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPTPN22en_US
dc.subjectSingle nucleotide polymorphismen_US
dc.subjectTakayasu's arteritisen_US
dc.titlePTPN22 gene polymorphism in Takayasu's arteritisen_US
dc.typeArticleen_US

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