Severity Classification of Limbal Stem Cell Failure Due to Steven Johnson Syndrome in the Light of the Classification Consensus of Limbal Stem Cell Deficiency

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dc.contributor.authorAkgun, Zeynep
dc.contributor.authorPalamar, Melis
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorYagci, Ayse
dc.contributor.authorBarut Selver, Ozlem
dc.date.accessioned2024-08-31T07:49:33Z
dc.date.available2024-08-31T07:49:33Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives:To examine and to understand the limbal stem-cell deficiency (LSCD) because of Steven-Johnson syndrome (SJS) in line with the new classification system for the first time in the literature.Methods:Medical records of patients with LSCD because of SJS were reviewed retrospectively. In addition to demographic data and ophthalmologic or systemic findings, anterior segment photographs of the patients were reviewed retrospectively. Limbal stem-cell deficiency severity was graded according to the classification published by the Limbal Stem Cell Working Group.Results:Twenty-four eyes of 14 patients with eye involvement secondary to SJS were included in the study. The mean age of the patients was 36.09 +/- 16.70 (9-58) years and the female-to-male ratio was 11:3. The anterior segment photographs of the patients were evaluated by two independent masked observers. Limbal stem-cell deficiency severity was graded according to the classification published by Deng et al. Corneal opacity was divided into three stages according to the area of involvement. Corneal opacity was classified as Stage I if the central 5 mm region of the cornea was not affected, as Stage II if the central 5 mm region of the cornea was affected, and as Stage III if the entire corneal surface was affected. Limbal involvement was classified as Stage A if it was below 50%, as Stage B if it was between 50% and 100%, and as Stage C if it was 100%.Conclusion:This is the first study in the literature to describe and classify LSCD because of SJS, according to the new LSCD classification. Consistent with the results, LSCD follows a bimodal distribution. Most patients demonstrated severe (Stage III-32.14%) or mild (Stage IA-21.42%) LSCD.en_US
dc.identifier.doi10.1097/ICL.0000000000001073
dc.identifier.endpage162en_US
dc.identifier.issn1542-2321
dc.identifier.issn1542-233X
dc.identifier.issue4en_US
dc.identifier.pmid38305421en_US
dc.identifier.scopus2-s2.0-85188836706en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage159en_US
dc.identifier.urihttps://doi.org/10.1097/ICL.0000000000001073
dc.identifier.urihttps://hdl.handle.net/11454/104913
dc.identifier.volume50en_US
dc.identifier.wosWOS:001189912200006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEye & Contact Lens-Science and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectLimbal Stem Cellsen_US
dc.subjectLimbal Stem-Cell Deficiencyen_US
dc.subjectSteven-Johnson Syndromeen_US
dc.titleSeverity Classification of Limbal Stem Cell Failure Due to Steven Johnson Syndrome in the Light of the Classification Consensus of Limbal Stem Cell Deficiencyen_US
dc.typeArticleen_US

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