Anti toxic effect of broccoli extract on stannous dichloride toxicity [Efeito antitóxico do extrato de brócolis na toxicidade do dicloreto de estanho]

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dc.contributor.authorCekic B.
dc.contributor.authorMuftuler F.Z.B.
dc.contributor.authorKilcar A.Y.
dc.contributor.authorGunay N.
dc.contributor.authorSakarya S.
dc.contributor.authorUnak P.
dc.date.accessioned2019-10-26T21:44:32Z
dc.date.available2019-10-26T21:44:32Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractPURPOSE: Since Technetium-99m (99mTc) has favorable physical and chemical characteristics, it is widely used radioisotope in Nuclear Medicine. However, stannous dichloride (SnCl2) has been widely used as a reducing agent in labeling procedure of pharmaceutical with radionuclide, it has been realized that SnCl2 have genotoxic and cytotoxic effects on biological systems. In previous studies, it has been shown that some herbal extract can reduce genotoxic and cytotoxic effects of SnCl2. In the present study, it is aimed to evaluate the effect of the broccoli extract on the survival of E. coli ATCC 25922 strain against to toxic effects of SnCl2. METHODS: Broccoli was extracted with methanol extraction. HPLC and TLC analysis of broccoli extract were performed. Then antitoxicity and dose response assays were performed on bacterial strain. RESULTS: The broccoli extract had dose dependent protective effect against SnCl2 toxic effect on E. coli. CONCLUSIONS: The consumption of broccoli may alter the stannous dichloride toxicity. Broccoli extract may use as a new protective strategies against the toxic effect of SnCl2 on patients who were taken 99mTc radiopharmaceuticals.en_US
dc.identifier.doi10.1590/S0102-86502012000900003en_US
dc.identifier.endpage610en_US
dc.identifier.issn0102-8650
dc.identifier.issue9en_US
dc.identifier.pmid22936084en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage606en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-86502012000900003
dc.identifier.urihttps://hdl.handle.net/11454/18460
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBroccolien_US
dc.subjectEchnetium-99men_US
dc.subjectEscherichia colien_US
dc.subjectStannous dichlorideen_US
dc.subjectToxicityen_US
dc.titleAnti toxic effect of broccoli extract on stannous dichloride toxicity [Efeito antitóxico do extrato de brócolis na toxicidade do dicloreto de estanho]en_US
dc.typeArticleen_US

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