Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects

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dc.authorscopusid57190403532
dc.authorscopusid57216431373
dc.authorscopusid57199151204
dc.authorscopusid55565668500
dc.authorscopusid57218439505
dc.authorscopusid57896128400
dc.contributor.authorKhaki-Khatibi, Fatemeh
dc.contributor.authorShademan, Behrouz
dc.contributor.authorGholikhani-Darbroud, Reza
dc.contributor.authorNourazarian, Alireza
dc.contributor.authorRadagdam, Saeed
dc.contributor.authorPorzour, Maghsoud
dc.date.accessioned2023-01-12T20:10:54Z
dc.date.available2023-01-12T20:10:54Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjectives Leptin polymorphism (LEP) has been associated with coronary heart disease (CAD), obesity, and high body mass index (BMI). However, we performed a systematic review and meta-analysis to discover the association because previous studies reached different conclusions. Methods Review Manager, version 5.3.5, and Stata, version 15.0, were used for statistical analysis. We calculated the effect size of the studies using the OR with the corresponding 95% CI, and two-sided (bilateral) p-values of 0.05 were considered significant. To determine heterogeneity among the selected studies, the Q test and I2 statistics were used. Meta-regression was used to examine the disease (heart disease, obesity, and high BMI) and heterogeneity between these subgroups. Results Eleven studies with 18,984 subjects were included in this study. The G-2548A (rs12112075), rs7799039, and A19G (rs2167270) polymorphisms of the leptin gene (but not the Lys656Asn (rs1805094) polymorphism) are associated with an increased risk of cardiovascular disease. Our pooled analysis revealed an association between the G-2548A (rs12112075) polymorphism and heart disease, high BMI, and obesity. This indicates that individuals carrying the AA allele are at an increased risk for heart disease, high BMI, and obesity. People with heart failure and coronary artery disease did not have the rs7799039 polymorphism or its alleles linked to them. Conclusions Combined analysis of data from current and published research suggests that the leptin gene polymorphisms G-2548A (rs12112075), rs7799039, and A19G (rs2167270) (but not the Lys656Asn (rs1805094) polymorphism) are associated with an increased risk of cardiovascular disease. Further research is needed to understand this association.en_US
dc.identifier.doi10.1515/hmbci-2022-0020
dc.identifier.issn1868-1883
dc.identifier.issn1868-1891
dc.identifier.pmid36103664en_US
dc.identifier.scopus2-s2.0-85138270709en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1515/hmbci-2022-0020
dc.identifier.urihttps://hdl.handle.net/11454/77975
dc.identifier.wosWOS:000853544500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofHormone Molecular Biology and Clinical Investigationen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbody mass indexen_US
dc.subjectcoronary artery diseaseen_US
dc.subjectleptinen_US
dc.subjectleptin receptoren_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectPlasma Leptinen_US
dc.subjectReceptor Geneen_US
dc.subjectAdipose-Tissueen_US
dc.subjectAssociationen_US
dc.subjectCanceren_US
dc.subjectAtherosclerosisen_US
dc.subjectResistanceen_US
dc.subjectVariantsen_US
dc.subjectFailureen_US
dc.titleGene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjectsen_US
dc.typeReviewen_US

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