Synthesis of 131I labeled estrone derivatives and biodistribution studies on rats

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dc.contributor.authorEnginar H.
dc.contributor.authorUnak P.
dc.contributor.authorLambrecht F.Y.
dc.contributor.authorBiber F.Z.
dc.contributor.authorMedine E.I.
dc.contributor.authorCetinkaya B.
dc.date.accessioned2019-10-27T08:59:19Z
dc.date.available2019-10-27T08:59:19Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study is to synthesize novel 131I labeled estrone derivatives that may have therapeutical potentials on Estrogen Receptor rich tumors. Two radiolabeled estrone derivatives, [131I]2-iodo-3- methoxy-estra-1,3,5-trien-17-one and [131I]4-iodo-3-methoxy-estra-1, 3,5-trien-17-one were synthesized. Ether amino estrone derivatives were obtained from estrone in three steps by means of diazonium compounds. Tissue distribution studies exhibited receptor-mediated uptake in target organs in female Albino Wistar rats. Maximum uptakes for 2-iodo[131I]-3- methoxy-estrone are in stomach, pancreas, intestines and uterus. A similar biodistribution profile was obtained for 4-iodo[131I]-3-methoxy- estrone. However 2-iodo-3-methoxy-estra-1,3,5-trien-17-one has higher uptake in stomach, kidneys, pancreas, and intestines than 4-iodo-derivative. © 2005 Akadémiai Kiadó.en_US
dc.description.sponsorshipThe authors acknowledge the financial support from Afyon Kocatepe University Scientific Research Funds, and the help of Dr. Cavit KAZAZ from Atatürk University at Erzurum, Turkey for kind assistance with NMR analyses. --en_US
dc.identifier.doi10.1007/s10967-005-0749-y
dc.identifier.endpage539en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage535en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-005-0749-y
dc.identifier.urihttps://hdl.handle.net/11454/27766
dc.identifier.volume264en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSynthesis of 131I labeled estrone derivatives and biodistribution studies on ratsen_US
dc.typeArticleen_US

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