Synthesis of 131I labeled estrone derivatives and biodistribution studies on rats
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study is to synthesize novel 131I labeled estrone derivatives that may have therapeutical potentials on Estrogen Receptor rich tumors. Two radiolabeled estrone derivatives, [131I]2-iodo-3- methoxy-estra-1,3,5-trien-17-one and [131I]4-iodo-3-methoxy-estra-1, 3,5-trien-17-one were synthesized. Ether amino estrone derivatives were obtained from estrone in three steps by means of diazonium compounds. Tissue distribution studies exhibited receptor-mediated uptake in target organs in female Albino Wistar rats. Maximum uptakes for 2-iodo[131I]-3- methoxy-estrone are in stomach, pancreas, intestines and uterus. A similar biodistribution profile was obtained for 4-iodo[131I]-3-methoxy- estrone. However 2-iodo-3-methoxy-estra-1,3,5-trien-17-one has higher uptake in stomach, kidneys, pancreas, and intestines than 4-iodo-derivative. © 2005 Akadémiai Kiadó.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
264
Sayı
3
