The investigation of the antitumor agent toxicity and capsaicin effect on the electron transport chain enzymes, catalase activities and lipid peroxidation levels in lung, heart and brain tissues of rats

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dc.contributor.authorKursunluoglu G.
dc.contributor.authorTaskiran D.
dc.contributor.authorKayali H.A.
dc.date.accessioned2019-10-27T08:01:34Z
dc.date.available2019-10-27T08:01:34Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractCisplatin is one of the most active cytotoxic agents in cancer treatment. To clarify the interaction with mitochondria, we hypothesize that the activities of mitochondrial electron transport chain (ETC) enzymes succinate dehydrogenase (SDH) and cytochrome c oxidase (COX), nucleotide levels, as well as levels of catalase (CAT) enzyme and membrane lipid peroxidation (LPO) can be affected by cisplatin. There was a significant decrease of both SDH and COX activities in the lung, heart, and brain tissues at the 1st day after cisplatin exposure, and the observed decreased levels of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) in comparison with the control could be because of cisplatin-induced mitochondrial dysfunction. The investigations suggested that cisplatin inhibits SDH, COX, and ATP synthase. The higher LPO level in the studied tissues after 1 and 4 days post-exposure to cisplatin compared to control can be inferred to be a result of elevated electron leakage from the ETC, and reactive oxygen species (ROS) can lead to wide-ranging tissue damage such as membrane lipid damage. Consequently, it was observed that capsaicin may have a possible protective effect on ETC impairment caused by cisplatin. The activities of SDH and COX were higher in heart and brain exposed to cisplatin + capsaicin compared to cisplatin groups, while LPO levels were lower. The investigated results in the cisplatin + capsaicin groups suggested that the antioxidant capacity of capsaicin scavenges ROS and prevents membrane destruction. © 2018 by the authors.en_US
dc.identifier.doi10.3390/molecules23123267en_US
dc.identifier.issn1420-3049
dc.identifier.issue12en_US
dc.identifier.pmid30544766en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/molecules23123267
dc.identifier.urihttps://hdl.handle.net/11454/25022
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectATP–ADPen_US
dc.subjectCapsaicinen_US
dc.subjectCATen_US
dc.subjectCisplatinen_US
dc.subjectETCen_US
dc.subjectLPOen_US
dc.titleThe investigation of the antitumor agent toxicity and capsaicin effect on the electron transport chain enzymes, catalase activities and lipid peroxidation levels in lung, heart and brain tissues of ratsen_US
dc.typeArticleen_US

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