Fluvastatin alleviates doxorubicin-induced cardiac and renal toxicity in rats via regulation of oxidative stress, inflammation, and apoptosis associated genes expressions

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dc.authoridKUŞÇU, Gökçe Ceren/0000-0003-1750-8209
dc.authoridKarabay Yavasoglu, N.Ulku/0000-0002-7483-0184
dc.authoridBUHUR, Aylin/0000-0002-3759-6616
dc.authoridYavasoglu, Altug/0000-0003-4227-1637
dc.authorscopusid57208213974
dc.authorscopusid57208215503
dc.authorscopusid57207940063
dc.authorscopusid8633854100
dc.authorscopusid6701658370
dc.authorscopusid8955041400
dc.authorscopusid55318033800
dc.authorwosidGUREL, ÇEVİK/AAA-1277-2021
dc.authorwosidKUŞÇU, Gökçe Ceren/B-6557-2016
dc.contributor.authorKuscu, Gokce Ceren
dc.contributor.authorGurel, Cevik
dc.contributor.authorBuhur, Aylin
dc.contributor.authorYavasoglu, Nefise Ulku Karabay
dc.contributor.authorKose, Timur
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorOltulu, Fatih
dc.date.accessioned2023-01-12T19:59:05Z
dc.date.available2023-01-12T19:59:05Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractDoxorubicin (DOXO) is a cytostatic agent used in the chemotherapy protocol of several cancers for more than 40 years, but usage of this drug in cancer treatment has been limited due to severe renal and cardiac tissue toxicities that may result in death in patients. Fluvastatin (FV) is a fully synthetic hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor used as a cholesterol-lowering agent in patients with hypercholesterolemia. Previous studies revealed that FV also exhibits antioxidant, anti-inflammatory, and antitumor activity. Additionally, our previous study indicated that FV exerts a prophylactic effect on DOXO-induced testicular toxicity by preventing lipid peroxidation, supporting the antioxidant system, and regulating the blood-testis barrier-associated genes expression. Herein, we purposed to evaluate the possible therapeutic and the protective effects of FV on the DOXO-induced cardiac and renal toxicitiy model by histochemical, immunohistochemical, biochemical, and real-time polymerase chain reaction (real-time PCR) analyses. Results point out protective use of FV exerts a beneficial effect by repressing lipid peroxidation and by regulating the inducible nitric oxide synthase (iNOS), nitric oxide synthase endothelial (eNOS), nuclear factor kappa-B (NF-kappa B), and Caspase-3 (Casp3) protein and mRNA expressions, which play an important role in mediating DOXO-induced renal and cardiac toxicity mechanisms. In conclusion, FV may be a candidate agent for the prevention of renal and cardiac toxicities in cancer patients receiving DOXO chemotherapy.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Unit [18-TIP-016]en_US
dc.description.sponsorshipThis study was supported by the Ege University Scientific Research Projects Coordination Unit [grant number 18-TIP-016 (to FO)].en_US
dc.identifier.doi10.1080/01480545.2022.2043351
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.pmid35209778en_US
dc.identifier.scopus2-s2.0-85125907927en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2022.2043351
dc.identifier.urihttps://hdl.handle.net/11454/77095
dc.identifier.wosWOS:000761723900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectcardiac toxicityen_US
dc.subjectdoxorubicinen_US
dc.subjectfluvastatinen_US
dc.subjectinflammationen_US
dc.subjectrenal toxicityen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectNf-Kappa-Ben_US
dc.subjectInduced Cardiotoxicityen_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectInduced Cardiomyopathyen_US
dc.subjectDamageen_US
dc.subjectProtectsen_US
dc.subjectAtorvastatinen_US
dc.subjectMechanismsen_US
dc.subjectInosen_US
dc.titleFluvastatin alleviates doxorubicin-induced cardiac and renal toxicity in rats via regulation of oxidative stress, inflammation, and apoptosis associated genes expressionsen_US
dc.typeArticleen_US

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