N-acetyltransferase 2 gene polymorphisms and susceptibility to prostate cancer: a pilot study in the Turkish population
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tubitak Scientific & Technical Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To Investigate the association between the 3 most frequently observed single nucleotide polymorphisms of the NAT2 gene and the risk of developing prostate cancel in the Turkish population. Materials and methods: A total of 110 unrelated patients with prostate cancer were Included in this case-control association study and constituted the study group The control group also consisted of 150 unrelated but healthy men Genomic DNA was Isolated from peripheral blood leukocytes of all patients and analyzed with a sensitive real-time PCR method After melting curve analysis genotypes were Identified for the NAT2*5A, NAT2*6A, and NAT2*7A/B polymorpisms Results: Prostate cancer patients had a higher frequency of the mutant NAT2*6A (13.6% versus 4.0%, P = 0 009) and heterozygote NAT2*7A/B (20 9% versus 9 3%, P = 0 008) genotypes when compared with the controls Conclusion: The NAT2*6A and NAT2*7A/B gene polymorphisms were significantly associated with prostate cancer in the Turkish population Real-time PCR analysis of the NAT2 acetylator phenotype can therefore be used to recognize individuals with a high risk of developing prostate cancer
Açıklama
Anahtar Kelimeler
N-Acetyltransferase 2, prostate cancer, acetylator phenotype
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
40
Sayı
4
