Expression of Epstein-Barr-virus-encoded small nuclear RNA in nasopharyngeal carcinomas of Aegean Turkish patients

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dc.contributor.authorErtan, Yesim
dc.contributor.authorHekimgil, Mine
dc.contributor.authorKaraarslan, Serap
dc.contributor.authorSoydan, Saliha
dc.date.accessioned2019-10-27T19:54:47Z
dc.date.available2019-10-27T19:54:47Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractNasopharyngeal carcinomas (NPC) are epithelial neoplasms which show a distinct geographical distribution and have a characteristic histology. These tumors have multifactorial etiology, including virological, environmental, and genetic components. The aim of the present study is to assess the relation between Epstein-Barr-virus (EBV) and subtypes of NPC in Aegean Turkish patients. In the present study, nasopharyngeal biopsies of 84 cases diagnosed as nasopharyngeal carcinoma, between 1998 and 2004, were reevaluated. In situ hybridization with the fluorescein-conjugated EBV-encoded small nuclear RNA (EBER) oligonucleotide probe was performed on paraffin-embedded tissue sections using an automated slide stainer system. Of 84 patients, 55 were men and 29 were women with ages ranging between 7 and 77 years (median 50, mean 46.73). Seventy-three of 84 cases were EBER positive. All of 62 cases (100.0%) with undifferentiated carcinoma, 8 of 16 (50.0%) with differentiated nonkeratinizing carcinoma, and three of six (50.0%) with keratinizing squamous cell carcinoma were EBV positive. EBER positivity was statistically significantly higher in undifferentiated carcinomas, compared to the other morphological subtypes (p=0.000). Our results showed that all morphological subtypes of NPC are highly associated with EBV latent infection in our region, and a higher prevalence was found for the undifferentiated subtype.en_US
dc.identifier.doi10.1007/s00428-008-0589-6en_US
dc.identifier.endpage414en_US
dc.identifier.issn0945-6317
dc.identifier.issue4en_US
dc.identifier.pmid18299891en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage411en_US
dc.identifier.urihttps://doi.org/10.1007/s00428-008-0589-6
dc.identifier.urihttps://hdl.handle.net/11454/40572
dc.identifier.volume452en_US
dc.identifier.wosWOS:000254207900008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofVirchows Archiven_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnasopharyngeal carcinomaen_US
dc.subjectEBERen_US
dc.subjectin situ hybridizationen_US
dc.titleExpression of Epstein-Barr-virus-encoded small nuclear RNA in nasopharyngeal carcinomas of Aegean Turkish patientsen_US
dc.typeArticleen_US

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