Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment

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dc.contributor.authorBayraktaroğlu, Selen
dc.contributor.authorAcar, Sezer
dc.contributor.authorTahta, Neryal
dc.contributor.authorAydınok, Yeşim
dc.contributor.authorGözmen, Salih
dc.contributor.authorAcar, Sultan O.
dc.contributor.authorVergin, Raziye C.
dc.date.accessioned2023-01-12T20:32:11Z
dc.date.available2023-01-12T20:32:11Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: There are a limited number of studies evaluating ironoverload in childhood leukemia by magnetic resonance imaging(MRI). The aim of this study was to determine liver iron content (LIC)by MRI in children with acute lymphoblastic leukemia (ALL) who hadcompleted treatment and to compare those values with serum ironparameters.Materials and Methods: A total of 30 patients between the ages of 7and 18 who had completed ALL treatment were included in the study.Serum iron parameters (serum iron, serum ferritin [SF], and total ironbinding capacity) and liver function tests were studied. R2 MRI wasperformed for determining LIC.Results: Normal LIC was detected in 22 (63.4%) of the cases. Seven(23.3%) had mild and 1 (3.3%) had moderate liver iron deposition. Incontrast, severe iron overload was not detected in any of the cases.LIC levels were correlated with the numbers of packed red blood cell(pRBC) transfusions (r=0.637, p<0.001), pRBC transfusion volume(r=0.449, p<0.013), SF levels (r=0.561, p=0.001), and transferrinsaturation (r=0.353, p=0.044). In addition, a positive correlationwas found between the number of pRBC transfusions and SF levels(r=0.595, p<0.001).Conclusion: We showed that the frequency of liver iron depositionwas low and clinically less significant after the end of treatment inchildhood ALL patients. LIC was demonstrated to be related to SF andtransfusion history. These findings support that SF and transfusionhistory may be used as references for monitoring iron accumulationor identifying cases for further examinations such as MRI.en_US
dc.identifier.doi10.4274/tjh.galenos.2020.2019.0364
dc.identifier.endpage270en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue4en_US
dc.identifier.startpage263en_US
dc.identifier.trdizinid430823en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2020.2019.0364
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/430823
dc.identifier.urihttps://hdl.handle.net/11454/81057
dc.identifier.volume37en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEvaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatmenten_US
dc.typeArticleen_US

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