Cord blood and consecutive chitotriosidase activity: Relationship to prematurity and early prognosis
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BackgroundThe aim of this study was to investigate the relationship between plasma chitotriosidase activity, an inflammatory protein secreted mainly from macrophages, and neonatal morbidity and mortality in premature infants. MethodsCord blood chitotriosidase activity was studied in healthy control infants (53 term, group 1; 26 late preterm [33-37gestational weeks], group 2) and 35 preterm infants (32weeks; group 3). In group 3, consecutive samples at 3h, 24h, 72h, 7days, 14days, and 36weeks after conception were also analyzed. Group 3 was also evaluated for mortality, respiratory treatment and bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). ResultsCord blood chitotriosidase activity was positively correlated with gestational age and birthweight. SNAPPE-II score was correlated with chitotriosidase activity at 24h. Consecutive chitotriosidase activity for group 3 was non-significantly higher in infants who died in the early neonatal period. Higher chitotriosidase activity was observed in mechanically ventilated infants than infants treated with non-invasive assisted ventilation. BPD, PDA, IVH and ROP, but not NEC, were related to higher chitotriosidase activity, being significant at some of the time points. ConclusionNeonatal stress such as invasive ventilation may create a risk for the development of BPD, PDA, IVH, and ROP by increasing macrophage activation in preterm infants as reflected in the higher chitotriosidase activity. High chitotriosidase activity may also be associated with disease severity and mortality.
Açıklama
Anahtar Kelimeler
chitotriosidase, morbidity, mortality, newborn, prematurity
Kaynak
Pediatrics International
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
57
Sayı
3
