Azithromycin as an Adjunctive Treatment of Generalized Severe Chronic Periodontitis: Clinical, Microbiologic, and Biochemical Parameters

Basit Öğe Kaydı
dc.contributor.authorHan, Buket
dc.contributor.authorEmingil, Gulnur
dc.contributor.authorOzdemir, Guven
dc.contributor.authorTervahartiala, Taina
dc.contributor.authorVural, Caner
dc.contributor.authorAtilla, Gul
dc.contributor.authorBaylas, Haluk
dc.contributor.authorSorsa, Timo
dc.date.accessioned2019-10-27T21:40:46Z
dc.date.available2019-10-27T21:40:46Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: This study examines the efficacy of azithromycin in combination with non-surgical periodontal therapy on clinical and microbiologic parameters and gingival crevicular fluid (GCF) matrix metalloproteinases-8 (MMP-8) levels over 6 months in patients with severe generalized chronic periodontitis (CP). Methods: Twenty-eight of 36 patients with severe generalized CP were included in this randomized, double-masked, placebo-controlled, parallel-arm study. They were randomly assigned to azithromycin or placebo groups (500 mg, once daily for 3 days). Probing depth (PD), clinical attachment level, dichotomous presence or absence of supragingival plaque accumulation, and bleeding on probing were recorded. GCF samples were obtained from one single-rooted tooth with PD >= 6 mm, whereas microbiologic samples were collected from two single-rooted teeth with PD >= 6 mm. Microbiologic parameters were analyzed by quantitative real-time polymerase chain reaction for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia, and total bacteria. GCF MMP-8 levels were determined by immunofluorescence assay. Results: Azithromycin and placebo groups demonstrated similar but significant improvements in all clinical parameters (P < 0.05). A. actinomycetemcomitans, P. gingivalis, T. forsythia, P. intermedia, and total bacteria significantly decreased over the 6-month period in both groups, whereas F. nucleatum was significantly reduced in all visits in the azithromycin group, with the levels also being lower compared with those of the placebo group (P < 0.05). The azithromycin and placebo groups exhibited significant reduction in GCF MMP-8 levels at the post-treatment visit and at 2 weeks (P < 0.05). Conclusion: On the basis of the present findings, it can be concluded that adjunctive azithromycin provides no additional benefit over non-surgical periodontal treatment on parameters investigated in patients with severe generalized CP. J Periodontol 2012;83:1480-1491.en_US
dc.description.sponsorshipEge UniversityEge University [06-Dental-016]; Academy of FinlandAcademy of Finland [1130408]; Research Foundation of Helsinki University Central Hospital [TYH 2012210]en_US
dc.description.sponsorshipThis work was supported by Ege University Research Projects Grant 06-Dental-016, Academy of Finland Grant 1130408, and Research Foundation of Helsinki University Central Hospital Grant TYH 2012210. The authors thank Dr. Timur Kose, Department of Biostatistics and Medical Informatics, School of Medicine, Ege University, Izmir, who performed statistical analysis. The authors report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1902/jop.2012.110519en_US
dc.identifier.endpage1491en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue12en_US
dc.identifier.pmid22324488en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1480en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2012.110519
dc.identifier.urihttps://hdl.handle.net/11454/46351
dc.identifier.volume83en_US
dc.identifier.wosWOS:000312355600007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibioticsen_US
dc.subjectazithromycinen_US
dc.subjectchronic periodontitisen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectmatrix metalloproteinase 8en_US
dc.subjectmicrobiologyen_US
dc.titleAzithromycin as an Adjunctive Treatment of Generalized Severe Chronic Periodontitis: Clinical, Microbiologic, and Biochemical Parametersen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu