First In Vitro-In Silico Analysis for the Determination of Antimicrobial and Antioxidant Properties of 2-(4-Methoxyphenylamino)-2-oxoethyl Methacrylate and p-Acetamide

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dc.authoridÇankaya, Nevin/0000-0002-6079-4987
dc.authoridTemuz, Mehmet Mursit/0000-0003-0091-1106
dc.contributor.authorTemuz, Mehmet Mursit
dc.contributor.authorCankaya, Nevin
dc.contributor.authorKorcan, Safiye Elif
dc.contributor.authorAzarkan, Serap Yalcin
dc.contributor.authorKahraman, Tugba
dc.date.accessioned2024-08-31T07:50:49Z
dc.date.available2024-08-31T07:50:49Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThe antibacterial, antifungal, and antioxidant activities of 2-chloro-N-(4-methoxyphenyl)acetamide (p-acetamide) and 2-(4-methoxyphenylamino)-2-oxoethyl methacrylate (MPAEMA) were investigated by in vitro experiments and in silico analyses. MPAEMA has an antibacterial effect only against Gram-positive Staphylococcus aureus. It was determined that this did not affect any other bacteria and Candida glabrata yeast. On the other hand, p-acetamide showed antimicrobial activity against S. aureus ATCC 25923, C. glabrata ATCC 90030, Bacillus subtilis NRRL 744, Enterococcus faecalis ATCC 551289, Escherichia coli ATCC 25922, Klebsiella pneumoniae NRLLB4420, Pseudomonas aeruginosa ATCC 27853, and Listeria monocytogenes ATCC 1911. p-Acetamide showed the greatest antifungal effect by inhibiting the colony growth of Trichoderma longibrachiatum (98%). This was followed by Mucor plumbeus with 83% and Fusarium solani with 21%. MPAEMA inhibited colony growth of T. longibrachiatum by 95% and that of M. plumbeus by 91%. Also, p-acetamide and MPAEMA had a scavenging effect on free radicals. According to results of the in silico analysis, the antimicrobial effect of these compounds is due to their effect on DNA ligase. Based on drug-likeness analysis, they were found to be consistent with the Lipinski, Veber, or Ghose rule. p-Acetamide and MPAEMA may be used as drugs.en_US
dc.description.sponsorshipAnatolian University Libraries Consortiumen_US
dc.description.sponsorshipThe authors thank ANKOS (Anatolian University Libraries Consortium) for providing financial support.en_US
dc.identifier.doi10.1021/acsomega.3c07836
dc.identifier.endpage7922en_US
dc.identifier.issn2470-1343
dc.identifier.issue7en_US
dc.identifier.pmid38405536en_US
dc.identifier.scopus2-s2.0-85185270730en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7910en_US
dc.identifier.urihttps://doi.org/10.1021/acsomega.3c07836
dc.identifier.urihttps://hdl.handle.net/11454/105389
dc.identifier.volume9en_US
dc.identifier.wosWOS:001164672000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofACS Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.titleFirst In Vitro-In Silico Analysis for the Determination of Antimicrobial and Antioxidant Properties of 2-(4-Methoxyphenylamino)-2-oxoethyl Methacrylate and p-Acetamideen_US
dc.typeArticleen_US

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