Potential novel biomarkers for diabetic testicular damage in streptozotocin-induced diabetic rats: Nerve growth factor beta and vascular endothelial growth factor

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dc.contributor.authorSisman A.R.
dc.contributor.authorKiray M.
dc.contributor.authorCamsari U.M.
dc.contributor.authorEvren M.
dc.contributor.authorAtes M.
dc.contributor.authorBaykara B.
dc.contributor.authorAksu I.
dc.contributor.authorGuvendi G.
dc.contributor.authorUysal N.
dc.date.accessioned2019-10-27T08:22:50Z
dc.date.available2019-10-27T08:22:50Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. It is well known that diabetes mellitus may cause testicular damage. Vascular endothelial growth factor (VEGF) and nerve growth factor beta (NGF-ß) are important neurotrophic factors for male reproductive system. Objective. We aimed to investigate the correlation between testicular damage and testicular VEGF and NGF-ß levels in diabetic rats. Methods. Diabetes was induced by streptozotocin (STZ, 45mg/kg/i.p.) in adult rats. Fiveweeks later testicular tissuewas removed; testicular VEGF and NGF-ß levels were measured by ELISA. Testicular damage was detected by using hematoxylin and eosin staining and periodic acid- Schiff staining, and apoptosis was identified by terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL). Seminiferous tubular sperm formation was evaluated using Johnsens score. Results. In diabetic rats, seminiferous tubule diameter was found to be decreased; basement membrane was found to be thickened in seminiferous tubules and degenerated germ cells. Additionally, TUNEL-positive cells were increased in number of VEGF+ cells and levels of VEGF and NGF-ß were decreased in diabetic testes. Correlation between VEGF and NGF-ß levels was strong. Conclusion. These results suggest that the decrease of VEGF and NGF-ß levels is associated with the increase of the apoptosis and testicular damage in diabetic rats. Testis VEGF and NGF-ß levels could be potential novel biomarkers for diabetes induced testicular damage. © Copyright 2014 Magorzata Guz et al.en_US
dc.identifier.doi10.1155/2014/108106en_US
dc.identifier.issn0278-0240
dc.identifier.pmid24771956en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2014/108106
dc.identifier.urihttps://hdl.handle.net/11454/26324
dc.identifier.volume2014en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofDisease Markersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePotential novel biomarkers for diabetic testicular damage in streptozotocin-induced diabetic rats: Nerve growth factor beta and vascular endothelial growth factoren_US
dc.typeArticleen_US

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