Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients

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dc.contributor.authorWong, G. K.
dc.contributor.authorGoldacker, S.
dc.contributor.authorWinterhalter, C.
dc.contributor.authorGrimbacher, B.
dc.contributor.authorChapel, H.
dc.contributor.authorLucas, M.
dc.contributor.authorAlecsandru, D.
dc.contributor.authorMcEwen, D.
dc.contributor.authorQuinti, I.
dc.contributor.authorMartini, H.
dc.contributor.authorSchmidt, R. E.
dc.contributor.authorErnst, D.
dc.contributor.authorEspanol, T.
dc.contributor.authorVidaller, A.
dc.contributor.authorCarbone, J.
dc.contributor.authorFernandez-Cruz, E.
dc.contributor.authorLougaris, V.
dc.contributor.authorPlebani, A.
dc.contributor.authorKutukculer, N.
dc.contributor.authorGonzalez-Granado, L. I.
dc.contributor.authorContreras, R.
dc.contributor.authorKiani-Alikhan, S.
dc.contributor.authorIbrahim, M. A. A.
dc.contributor.authorLitzman, J.
dc.contributor.authorJones, A.
dc.contributor.authorGaspar, H. B.
dc.contributor.authorHammarstrom, L.
dc.contributor.authorBaumann, U.
dc.contributor.authorWarnatz, K.
dc.contributor.authorHuissoon, A. P.
dc.date.accessioned2019-10-27T21:52:38Z
dc.date.available2019-10-27T21:52:38Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractSplenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly in the context of refractory autoimmune cytopenia and suspected lymphoma, but there are understandable concerns about the potential of compounding an existing immunodeficiency. With increasing use of rituximab as an alternative treatment for refractory autoimmune cytopenia, the role of splenectomy in CVID needs to be re-examined. This retrospective study provides the largest cohesive data set to date describing the outcome of splenectomy in 45 CVID patients in the past 40 years. Splenectomy proved to be an effective long-term treatment in 75% of CVID patients with autoimmune cytopenia, even in some cases when rituximab had failed. Splenectomy does not worsen mortality in CVID and adequate immunoglobulin replacement therapy appears to play a protective role in overwhelming post-splenectomy infections. Future trials comparing the effectiveness and safety of rituximab and splenectomy are needed to provide clearer guidance on the second-line management of autoimmune cytopenia in CVID.en_US
dc.description.sponsorship7th European framework grant EUROPAD.net [HEALTH-F2-2008-201549]; 7th European framework grant EUROPAD.net (BMBF) [01 EO 0803]; Great Ormond Street Hospital Childrens Charity [V1242]en_US
dc.description.sponsorshipWe would like to express our gratitude to all our collaborators who helped us gather this invaluable data and all those who had contributed to the discussion during the ESID Clinical working party workshop at Istanbul in October 2010. This work was supported by the 7th European framework grant EUROPAD.net (HEALTH-F2-2008-201549 to K. W. and B. G. and BMBF grant no. 01 EO 0803 to K. W.). The authors are responsible for the contents of this publication.en_US
dc.identifier.doi10.1111/cei.12039en_US
dc.identifier.endpage72en_US
dc.identifier.issn0009-9104
dc.identifier.issn1365-2249
dc.identifier.issue1en_US
dc.identifier.pmid23480186en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1111/cei.12039
dc.identifier.urihttps://hdl.handle.net/11454/47692
dc.identifier.volume172en_US
dc.identifier.wosWOS:000316212200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectautoimmune cytopeniaen_US
dc.subjectcommon variable immunodeficiencyen_US
dc.subjectsplenectomyen_US
dc.subjectsplenomegalyen_US
dc.titleOutcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patientsen_US
dc.typeArticleen_US

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