C-reactive protein and neopterin levels in healthy non-obese adults

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dc.contributor.authorBozdemir, AE
dc.contributor.authorBarutcuoglu, B
dc.contributor.authorDereli, D
dc.contributor.authorKabaroglu, C
dc.contributor.authorHabif, S
dc.contributor.authorBayindir, O
dc.date.accessioned2019-10-27T19:19:24Z
dc.date.available2019-10-27T19:19:24Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Obesity and increased waist-to-hip ratio, emphasizing the importance of truncal obesity, have been found to correlate positively with increased cardiovascular disease risk and mortality. Owing to the inflammatory nature of atherosclerosis, the aim of our study was to find possible correlations between body mass index and waist-to-hip ratio, and the inflammatory markers C-reactive protein (CRP) and neopterin in healthy lean and overweight adults. Methods: A total of 49 healthy adults ( mean age 42.4 +/- 1.8 years, 32 females and 17 males) were classified according to their body mass index (BMI) and waist-to-hip ratio values. CRP and neopterin levels were measured. Results: CRP levels were found to be significantly higher in the group with BMI >= 25 kg/m(2) compared to the group with BMI < 25 kg/m(2) ( p = 0.014). Subjects with increased waist-to-hip ratio displayed significantly higher serum CRP and neopterin levels (p = 0.014 and p=0.033, respectively) compared with the group in which the waist-to-hip ratio was < 0.9. A strong positive correlation was found between CRP and BMI in the whole group ( r=0.658, p=0.0001). Conclusions: Grouping overweight subjects according to their waist-to-hip ratio, which is an indicator of truncal obesity, seems to be convenient in studying the inflammatory process in relation to the elevation of adipose tissue. Elevated CRP and neopterin levels may be useful in the assessment of cardiovascular risk in overweight as well as obese subjects.en_US
dc.identifier.doi10.1515/CCLM.2006.055en_US
dc.identifier.endpage321en_US
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue3en_US
dc.identifier.pmid16519605en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.1515/CCLM.2006.055
dc.identifier.urihttps://hdl.handle.net/11454/38742
dc.identifier.volume44en_US
dc.identifier.wosWOS:000236203000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofClinical Chemistry and Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatherosclerosisen_US
dc.subjectbody mass indexen_US
dc.subjecthigh-sensitivity C-proteinen_US
dc.subjectinflammationen_US
dc.subjectneopterinen_US
dc.subjectwaist-to-hip ratioen_US
dc.titleC-reactive protein and neopterin levels in healthy non-obese adultsen_US
dc.typeArticleen_US

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