Electrochemical monitoring of the interaction between Temozolamide and nucleic acids by using disposable pencil graphite electrodes

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dc.contributor.authorAltay C.
dc.contributor.authorEksin E.
dc.contributor.authorCongur G.
dc.contributor.authorErdem A.
dc.date.accessioned2019-10-26T21:22:27Z
dc.date.available2019-10-26T21:22:27Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractAbstract Temozolomide (TMZ) is an anticancer drug used for the treatment of adult brain tumour and skin cancer. The biomolecular interaction between TMZ and DNA was investigated for the first time in this study using disposable pencil graphite electrodes (PGEs) in combination with electrochemical techniques. The surface confined interactions between TMZ and different type of nucleic acids were performed. Before/after surface confined interaction process, the oxidation signals of TMZ, guanine and adenine were measured using differential pulse voltammetry (DPV) and PGE and accordingly, the changes at the oxidation signals were evaluated. The detection limit (DL) was also estimated based on the oxidation signal of TMZ. The interaction of TMZ with single stranded poly [A], poly [G], or double stranded poly [A]-poly[T] and poly [G]-poly[C] was also explored. Moreover, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques were utilized for detection the interaction between TMZ and DNA. The features of this single-use electrochemical sensor was discussed in comparison to other reports that were developed for TMZ detection. © 2015 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.talanta.2015.07.017en_US
dc.identifier.endpage815en_US
dc.identifier.issn0039-9140
dc.identifier.pmid26452894en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage809en_US
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2015.07.017
dc.identifier.urihttps://hdl.handle.net/11454/16967
dc.identifier.volume144en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofTalantaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclic voltammetryen_US
dc.subjectDifferential pulse voltammetryen_US
dc.subjectDNA biosensoren_US
dc.subjectElectrochemical impedance spectroscopyen_US
dc.subjectPencil graphite electrodeen_US
dc.subjectTemozolomideen_US
dc.titleElectrochemical monitoring of the interaction between Temozolamide and nucleic acids by using disposable pencil graphite electrodesen_US
dc.typeArticleen_US

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