Etiological factors in young patients with Retinal Vein Occlusion

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dc.contributor.authorNalcaci, Serhad
dc.contributor.authorDegirmenci, Cumali
dc.contributor.authorAkkin, Cezmi
dc.contributor.authorMentes, Jale
dc.date.accessioned2019-10-27T09:41:24Z
dc.date.available2019-10-27T09:41:24Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To present the etiological factors of patients with Retinal Vein Occlusion (RVO) under the age of 50 years. Methods: The study was conducted at Ege University Medicine Faculty Department of Ophthalmology. The clinical records of patients with RVO under the age of 50 seen between January 2014 and March 2018 were analyzed retrospectively. Forty patients comprised the study. Detailed ophthalmologic examination was performed. Past medical history, drug use, thrombophilic features, hyperviscosity syndromes and pathologies that may cause vasculitis were noted. Results: Forty patients, 22 (55%) male and 18 (45%) female, were included. Mean age was 41.6 +/- 10.01 years. Mean intraocular pressure and best-corrected visual acuity were 16.8 +/- 5.47mmHg and 0.76 +/- 0.64 logMAR, respectively. Hyperhomocystenemia (15 patients, 37.5%), Behget's disease (three patients, 7.5%), diabetes and/or hypertension (16 patients, 40%), methylenetetrahydrofolate reductase gene mutation (11 patients, 27.5%), prothrombin gene mutation (four patients, 10%) and factor V Leiden mutation (five patients, 12.5%) were present among the patients as etiological factor. Multiple etiological factors were detected in 11 (27.5%) patients. Factor V Leiden mutation and methylenetetrahydrofolate reductase gene mutation were detected in one patient (2.5%) with Behget's disease. Four patients with diabetes and/or hypertension also had hyperhomocystenemia and one of them had additionally prothrombin gene mutation. Two patients with methylenetetrahydrofolate reductase gene mutation also had a factor V Leiden mutation and one of them had additionally a prothrombin gene mutation. Three patients with methylenetetrahydrofolate reductase gene mutation also had hyperhomocystenemia and one patient with prothrombin gene mutation also had methylenetetrahydrofolate reductase gene mutation. Conclusions: Etiological factors that might result in RVO in young individuals should be investigated in detail. Targeted therapies may help to prevent development of new RVOs and potential vascular problems in other organs.en_US
dc.identifier.doi10.12669/pjms.35.5.546en_US
dc.identifier.endpage1401en_US
dc.identifier.issn1682-024X
dc.identifier.issue5en_US
dc.identifier.pmid31489014en_US
dc.identifier.startpage1397en_US
dc.identifier.urihttps://doi.org/10.12669/pjms.35.5.546
dc.identifier.urihttps://hdl.handle.net/11454/28620
dc.identifier.volume35en_US
dc.identifier.wosWOS:000486927000039en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEtiological factorsen_US
dc.subjectRetinal vein occlusionen_US
dc.subjectYoung patientsen_US
dc.titleEtiological factors in young patients with Retinal Vein Occlusionen_US
dc.typeArticleen_US

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